Devimistat (CPI-613) - 10mM in DMSO , CAS No.95809-78-2

CAS: 95809-78-2 Cat. No.: D408575 분자식: C₂₂H₂₈O₂S₂ 분자량: 388.59 EC 번호: 804-408-7

GRADE & PURITY 10mM in DMSO

Synonyms

6,8-bis(benzylthio)octanoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Devimistat (CPI-613) Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. CPI-613 induces apoptosis in
In vitro

In vitro, CPI-613 produces the selective toxicity against several tumor cell lines including H460 human lung cancer cells and Saos-2 human sarcoma cells with EC50 of 120 μM and 120 μM, respectively. CPI-613 disrupts H460 cancer cell mitochondrial metabolism including inhibition of PDH complex activity and loss of mitochondrial membrane potential in a time- and drug dose-dependent fashion. In addition, CPI-613 (240 μM) also induces both apoptotic and non-apoptotic cell death in H460 human lung cancer and Saos-2 human sarcoma cells.

In vivo

CPI-613 (25 mg/kg) has potent anticancer activity in a human tumor xenograft model of of a pancreatic tumor cell (BxPC-3). Similarly, CPI-613 (10 mg/kg) also produces significant tumor growth inhibition of H460 human non-small cell lung carcinoma in mouse model. Besides, CPI-613 produces little or no side-effect toxicity in expected therapeutic dose ranges in large animal models and has the maximum tolerated dose of 100 mg/kg in mice.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

동의어

6,8-bis(benzylthio)octanoic acid

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. CPI-613 induces apoptosis in pancreatic cancer cells

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 이성체 SMILES: C1=CC=C(C=C1)CSCCC(CCCCC(=O)O)SCC2=CC=CC=C2
• WGK 독일: 3
• 분자량: 388.59
• Reaxy-Rn: 3424180
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3424180&ln=

화학 및 물리적 특성

• 녹는점(°C): 70 °C

참고 문헌

1. Jinxin Yu, Jiayi He, Xuefeng Zhang, Chuxiao Lin, Shiyan Liu, Xin Gong, Xinnian Zeng, Jiali Liu.  (2024)  Differential energy pathways are required for rapid long-term memory formation in the oriental fruit fly, Bactrocera dorsalis.  Journal of Integrative Agriculture,      [PMID:] [10.1016/j.jia.2024.12.015]

2. Haiqin Wang, Yibin Zhang, Yu Jiang, Ruohong Xiang, Han Gong, Yanfei Gong, Hao Xu, Zekang Ma, Yifang Xie, Yu Zhu, Bin Hu, Xiao He, Jing Liu, Ji Zhang, Xiaojuan Xiao.  (2024)  The function and mechanism of clinical trial agent CPI-613 in multiple myeloma.  BIOCHEMICAL PHARMACOLOGY,      [PMID:39675585] [10.1016/j.bcp.2024.116717]

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 95809-78-2, the molecular formula is C22H28O2S2, and the molecular weight is 388.59 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.