DM1-SMe - ≥98% , CAS No.138148-68-2

CAS: 138148-68-2 Cat. No.: D646368 분자식: C₃₆H₅₀ClN₃O₁₀S₂ 분자량: 784.4 PubChem CID: 131873213

GRADE & PURITY ≥98%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent agent Maytansine, with IC 50 s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines

Form:Solid

IC50& Target:Maytansinoids

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent agent Maytansine, with IC 50 s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.

보관 조건

Protected from light,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

순수함

≥98%

이름과 식별자

• 정식 스마일: CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCSSC)C)C)OC)(NC(=O)O2)O
• IUPAC Name: [(1S,2R,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl-[3-(methyldisulfanyl)propanoyl]amino]propanoate
• InChIKey: ZLUUPZXOPGORNG-UDXCHANISA-N
• INCHI: 1S/C36H50ClN3O10S2/c1-20-11-10-12-27(47-8)36(45)19-26(48-34(44)38-36)21(2)32-35(4,50-32)28(49-33(43)22(3)39(5)29(41)13-14-52-51-9)18-30(42)40(6)24-16-23(15-20)17-25(46-7)31(24)37/h10-12,16-17,21-22,26-28,32,45H,13-15,18-19H2,1-9H3,(H,38,44)/b12-10-,20-11-/t21-,22+,26+,27-,28+,32+,35+,36+/m1/s1
• PubChem CID: 131873213
• 분자량: 784.4

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (127.49 mM; Need ultrasonic)