DMNQ - ≥99% , CAS No.6956-96-3

CAS: 6956-96-3 Cat. No.: D274695 분자식: C₁₂H₁₀O₄ 분자량: 218.21 EC 번호: 636-211-5

등급 & 순도 ≥99%

Synonyms

2,3-dimethoxy-1,4-naphthalenedione|dmnq|DiMeNQ;NSC 69355; NSC-69355; NSC69355;2,3-Dimethoxy-1,4-naphthoquinone|2,3-DIMETHOXY-1,4-DIHYDRONAPHTHALENE-1,4-DIONE|2,3-Dimethoxynaphthoquinone #|Lopac-D-5439|SDCCGSBI-0050385.P002|1,4-Naphthalenedione, 2,3-dimethoxy-|1,4-Naphthalenedione,2,3-dimethoxy-|2,3-Dimethoxynaphthoquinone|2,3-dimethoxynaphthalene-1,4-dione|2,3-DIMETHOXY-P-NAPHTHOQUINONE|2,3-Dimethoxy[1,4]naphthoquinone|2,3-Dimethoxy-1,4-naphthoquinone

Storage

20°C, 건조 보관

Shipped In

아이스 박스 + 아이스 패드

개요

20°C에서 보관하십시오. 건조 조건에서 보관하세요. 최대 12개월까지 보관할 수 있습니다.

사양

동의어

2,3-dimethoxy-1,4-naphthalenedione | dmnq | DiMeNQ;NSC 69355; NSC-69355; NSC69355;2,3-Dimethoxy-1,4-naphthoquinone | 2,3-DIMETHOXY-1,4-DIHYDRONAPHTHALENE-1,4-DIONE | 2,3-Dimethoxynaphthoquinone # | Lopac-D-5439 | SDCCGSBI-0050385.P002 | 1,4-Naphthalenedione, 2,3-dimethoxy- | 1,4-Naphthalenedione,2,3-dimethoxy- | 2,3-Dimethoxynaphthoquinon Show more

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

세포 투과성, 비알킬화 산화 환원 사이클링 퀴논. 시험관 내에서 슈퍼옥사이드 생성을 생성하고 세포 증식, 세포 사멸 및 괴사를 유도합니다. 산화 환원 순환제. 생체 내 및 시험관 내에서 활성 .

보관 조건

20°C, 건조 보관

배송

아이스 박스 + 아이스 패드

참고

가능하면 당일에 용액을 준비하여 사용하는 것이 좋습니다. 그러나 미리 원액을 만들어야 하는 경우에는 -20°C에서 단단히 밀봉된 바이알에 소량씩 보관하는 것이 좋습니다. 일반적으로 최대 한 달 동안 사용할 수 있습니다. 사용하기 전에 바이알을 개봉하기 전에 제품을 실온에서 1시간 이상 평형화할 것을 권장합니다. 용해도, 사용법 및 취급에 대한 추가 정보가 필요하신가요? 자주 묻는 질문(FAQ) 페이지에서 자세한 내용을 확인하세요.

순수함

≥99%

이름과 식별자

Pubchem Sid

508810508

정식 스마일

COC1=C(C(=O)C2=CC=CC=C2C1=O)OC

IUPAC Name

2,3-dimethoxynaphthalene-1,4-dione

InChIKey

ZEGDFCCYTFPECB-UHFFFAOYSA-N

INCHI

1S/C12H10O4/c1-15-11-9(13)7-5-3-4-6-8(7)10(14)12(11)16-2/h3-6H,1-2H3

이성체 SMILES

COC1=C(C(=O)C2=CC=CC=C2C1=O)OC

분자량

218.21

Reaxy-Rn

2049895

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2049895&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Naphthalenes
      • Subclass Naphthoquinones

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Naphthalenes
• Subclass: Naphthoquinones
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthoquinones
• Alternative Parents: Quinones Aryl ketones Vinylogous esters Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Naphthoquinone - Aryl ketone - Quinone - Vinylogous ester - Ketone - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as naphthoquinones. These are compounds containing a naphthohydroquinone moiety, which consists of a benzene ring linearly fused to a bezene-1,4-dione (quinone).
• External Descriptors: naphthoquinone

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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VDR Tclin Vitamin D receptor (26531 Activities)

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ELANE Tclin Leukocyte elastase (8173 Activities)

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POLB Tchem DNA polymerase beta (23632 Activities)

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CDC25A Tchem Dual specificity phosphatase Cdc25A (619 Activities)

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APP Tclin Amyloid-beta A4 protein (8510 Activities)

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ARSA Tbio Cerebroside-sulfatase (655 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

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ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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MAP2K7 Tchem Dual specificity mitogen-activated protein kinase kinase 7 (1145 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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AGS (1999 Activities)

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HL-60 (67320 Activities)

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J82 (505 Activities)

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MCF7 (126967 Activities)

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MRC5 (9203 Activities)

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SH-SY5Y (11521 Activities)

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SK-MES-1 (413 Activities)

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THP-1 (11052 Activities)

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U-937 (7138 Activities)

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A549 (127892 Activities)

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HEK293 (82097 Activities)

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Jurkat (10389 Activities)

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LS174T (446 Activities)

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PBMC (10003 Activities)

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FEN1 Tchem Flap endonuclease 1 (12055 Activities)

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HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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POLH Tchem DNA polymerase eta (21678 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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THPO Tbio Thrombopoietin (834 Activities)

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EYA2 Tbio Eyes absent homolog 2 (5884 Activities)

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GMNN Tbio Geminin (128009 Activities)

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RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)

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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

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HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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관련 대상(비인간)

Cdc25b Dual specificity phosphatase Cdc25B (32 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Plasmodium falciparum (966862 Activities)

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lef Anthrax lethal factor (7585 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)

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작용 메커니즘

화학 및 물리적 특성

• 용해성: Soluble in DMSO to 25 mM
• 분자량: 218.200 g/mol
• XLogP3: 1.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 218.058 Da
• Monoisotopic Mass: 218.058 Da
• Topological Polar Surface Area: 52.600 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 322.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1