DMT1 blocker 2 - 10mM in DMSO , CAS No.1062648-63-8

CAS: 1062648-63-8 Cat. No.: D656679 분자식: C₁₆H₁₃N₃O 분자량: 263.29

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 ( DMT1 ), with an IC 50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo

In Vitro

DMT1 blocker 2 (Compound 12f) (10 μM; 24 h) has no cytotoxic to HepG2 cells. DMT1 blocker 2 (10 μM) inhibits 44% of CYP3A4 activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks Dosage: 50 mg/kg Administration: Oral gavage followed 1 h later by an iron challenge Result: Attenuated the post-challenge serum iron increase.

IC50& Target:IC50: 0.83 μM (divalent metal transporter 1)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 ( DMT1 ), with an IC 50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

• 분자량: 263.29