등급 & 순도Moligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™, 10mM in DMSO Moligand™ 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.
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보관 및 배송
Argon charged,Store at -80°C Dry ice packs + Cold packs 출고. 정확한 사양은 로트별 COA를 확인하세요.
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품질 문서
SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.
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문헌적 근거
크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 0편에서 인용되었습니다.
개요
DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 ( ABHD12 ), with an IC 50 of 11 nM.
In Vitro
DO-264 displays an IC 50 value of 11 nM (9.6 nM-13 nM). DO-264 blocks lyso-PS hydrolysis activities of recombinant mouse and human ABHD12 in transfected HEK293T cell lysates (DO-264 IC 50 values of ~30 and 90 nM against mouse and human ABHD12, respectively) and the ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain (IC 50 =2.8 nM, 2.4 nM-3.3 nM) and human THP-1 cells (IC 50 = 8.6 nM, 6.3 nM-12 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Mice treated with DO-264 display dose-dependent increases in brain lyso-PS and 20:4 PS content that are qualitatively similar to the changes observed in ABHD12 –/– mice. DO-264-treated mice, however, show minimal impairment in auditory function following four weeks of drug exposure. Both ABHD12 –/– and DO-264-treated mice display exacerbated immunopathology following infection with the lymphocytic choriomeningitis virus (LCMV) clone 13, resulting in severe inflammatory lung damage, heightened chemokine production, and, in some cases, death . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 11 nM (ABHD12)
사양
사양 및 순도
Moligand™, 10mM in DMSO
생화학 및 생리적 메커니즘
DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 ( ABHD12 ), with an IC 50 of 11 nM.
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