DOTAGA-anhydride - ≥95% , CAS No.1375475-53-8

CAS: 1375475-53-8 Cat. No.: D1424089 분자식: C₁₉H₃₀N₄O₉ 분자량: 458.46

GRADE & PURITY ≥95%

Synonyms

DOTAGA-Anhydride | 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid,10-(tetrahydro-2,6-dioxo-2H-pyran-3-yl)Chemicalbook- | 2,2',2''-(10-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triaceticacid

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.

Specifications

동의어

DOTAGA-Anhydride | 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid,10-(tetrahydro-2,6-dioxo-2H-pyran-3-yl)Chemicalbook- | 2,2',2''-(10-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triaceticacid

사양 및 순도

≥95%

보관 조건

Store at -20°C,Argon charged

배송

Ice chest + Ice pads

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순수함

≥95%

이름과 식별자

분자량

458.46

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1375475-53-8, the molecular formula is C19H30N4O9, and the molecular weight is 458.46 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.