DX600 TFA - ≥99% , CAS No.D414451

CAS: D414451 Cat. No.: D414451 분자식: C₁₄₁H₁₈₅N₃₅O₄₀S₂ 분자량: 3074.32

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Information

DX600 DX600 is a specific inhibitor of angiotensin-converting enzyme 2 (ACE2) that does not cross-react with ACE.

Targets

ACE2

In vitro

DX600 is an ACE2 specific inhibitor that does not cross-react with ACE. Three human cell lines (Calu-3, Caco-2, Huh-7) are evaluated for the cell surface expression of ACE2 by flow cytometry and Western blot. Subsequently, whole cell lysates, cell culture supernatant, and live cells are evaluated in the assay. Calu-3 has elevated levels of ACE2 compared to Caco-2 or Huh-7. Calu-3 also demonstrates elevated ACE2 enzymatic activity in all three sources and can be inhibited by DX600.

In vivo

Mouse ACE2-driven Ang-(1-7) formation from Ang II is blocked by MLN-4760 but not by either linear or cyclic DX600. DX600 only blocks human ACE2 activity.

Cell Research(from reference)

Cell lines：Three human cell lines (Calu-3, Caco-2, Huh-7) 

Concentrations：10 μM 

Incubation Time：1 h 

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

DX600 is a specific inhibitor of angiotensin-converting enzyme 2 (ACE2) that does not cross-react with ACE.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

• 분자량: 3074.32

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro Water: 100 mg/mL (32.52 mM)