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Ecopipam hydrobromide - ≥99% , CAS No.2587360-22-1
주문 가능
등급 & 순도 ≥99%
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
이 등급을 선택하는 이유
≥99% 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.
보관 및 배송
Store at -20°C,Desiccated Ice chest + Ice pads 출고. 정확한 사양은 로트별 COA를 확인하세요.
품질 문서
SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.
문헌적 근거
크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 0편에서 인용되었습니다.
개요
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor , with K i s of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (K i =0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity
In Vitro
Ecopipam (2 μM) hydrobromide completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ecopipam (10, mg/kg, oral administration) antagonizes Apomorphine-induced stereotypy in rats. Ecopipam (5 and 10 μM, perfusion, 1 μL/min) reversibly and dose-dependently decreases acetylcholine release in the rat striatum. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male young adult Long-Evans rats were injected with NicotineDosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg) Result: Dose-dependently reduced pressing on both active and inactive levers.
Form:Solid
IC50& Target:D 1 Receptor 1.2 nM (Ki) D 5 Receptor 2.0 nM (Ki) D 2 Receptor 980 nM (Ki) D 4 Receptor 5520 nM (Ki) 5-HT Receptor 80 nM (Ki) Alpha-2A adrenergic receptor 731 nM (Ki)
사양
사양 및 순도
≥99%
생화학 및 생리적 메커니즘
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor , with K i s of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor
보관 조건
Store at -20°C,Desiccated
배송
Ice chest + Ice pads
이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.
작업 유형
ANTAGONIST
순수함
≥99%
이름과 식별자
분자량
394.73
문서
📋 안전 데이터 시트(SDS)
위험성, 취급, 보관 및 규제 준수를 포괄하는 종합 문서.
<<<<<<< HEAD SDS 다운로드 → ======= SDS 다운로드 → >>>>>>> release248-p3고급 데이터
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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리뷰
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