EGFR-IN-1 TFA - ≥99% , CAS No.E659035

CAS: E659035 Cat. No.: E659035 분자식: C₃₀H₃₁F₃N₆O₆ 분자량: 628.6

등급 & 순도 ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

개요

EGFR-IN-1 TFA is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR . EGFR-IN-1 TFA displays strong antiprolife

Appearance:Solid

IC50& Target:EGFR L858R/T790M

In Vitro:EGFR-IN-1 TFA (compound 24) is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 TFA displays stron

In Vivo:EGFR-IN-1 TFA (30mg/kg; p.o.; daily for 2 weeks) displays significant tumor growth inhibition with no observed loss in body weight. EGFR-IN-1 TFA evaluates in a time course PD experiment upon oral dosing at 30mg/kg. EGFR-IN-1 TFA shows a >50% inhib

Biological Activity:EGFR-IN-1 TFA is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR . EGFR-IN-1 TFA displays strong antiprolife

사양

사양 및 순도

≥99%

보관 조건

Store at 2-8°C,Desiccated

배송

Wet ice

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작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

분자량

628.6

화학 및 물리적 특성

• 용해성: DMSO : 250 mg/mL (397.71 mM; Need ultrasonic)