ELN484228 - ≥98% , CAS No.312-63-0

CAS: 312-63-0 Cat. No.: E413638 분자식: C₁₂H₁₀FNO₂S 분자량: 251.28 EC 번호: 667-877-5

등급 & 순도 ≥98%

Synonyms

N-(p-Fluorophenyl)benzenesulfonamide | NSC 164389 | 4′-Fluorobenzenesulfonanilide | N-(4-Fluorophenyl)benzenesulfonamide | N-(4-Fluorophenyl)-benzenesulfonamide

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Information

ELN484228 is a cell-permeable blocker that targetsα-synuclein, a key protein in Parkinson’s disease.

사양

동의어

N-(p-Fluorophenyl)benzenesulfonamide | NSC 164389 | 4′-Fluorobenzenesulfonanilide | N-(4-Fluorophenyl)benzenesulfonamide | N-(4-Fluorophenyl)-benzenesulfonamide

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

ELN484228 is a cell penetrant α-synuclein ligand that rescues of α-synuclein induced disruption of vesicle trafficking and dopaminergic neuronal loss and neurite retraction. ELN484228 reverses a-synuclein induced impairment of phagocytosis and protects do

보관 조건

Protected from light,Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥98%

이름과 식별자

Pubchem Sid

504758356

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504758356

정식 스마일

C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)F

IUPAC Name

N-(4-fluorophenyl)benzenesulfonamide

InChIKey

AZORQGXJAXEIGC-UHFFFAOYSA-N

INCHI

1S/C12H10FNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H

이성체 SMILES

C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)F

분자량

251.28

Reaxy-Rn

2121725

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2121725&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Benzene and substituted derivatives
      • Subclass Sulfanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Benzene and substituted derivatives
• Subclass: Sulfanilides
• Intermediate Tree Nodes: Not available
• Direct Parent: Sulfanilides
• Alternative Parents: Benzenesulfonamides Benzenesulfonyl compounds Fluorobenzenes Organosulfonamides Aryl fluorides Aminosulfonyl compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzenesulfonamide - Sulfanilide - Benzenesulfonyl group - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Organosulfonic acid amide - Aminosulfonyl compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Organosulfur compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Aromatic homomonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as sulfanilides. These are organic aromatic compounds containing a sulfanilide moiety, with the general structure RS(=O)(=O)NC1=CC=CC=C1.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

작용 메커니즘

화학 및 물리적 특성

• 감도: light sensitive
• 분자량: 251.280 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 251.042 Da
• Monoisotopic Mass: 251.042 Da
• Topological Polar Surface Area: 54.600 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 325.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1