Eltanexor Z-isomer - ≥96% , CAS No.1642300-78-4

CAS: 1642300-78-4 Cat. No.: E650555 분자식: C₁₇H₁₀F₆N₆O 분자량: 428.29 PubChem CID: 117763569

GRADE & PURITY ≥96%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.IC50：In Vitro: Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC 50 s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.In Vivo:

Form:Solid

Specifications

사양 및 순도

≥96%

생화학 및 생리적 메커니즘

Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.\nIC50：\nIn Vitro: Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC 50 s of 100 nM-50 μM, < 10

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

작업 유형

INHIBITOR

순수함

≥96%

이름과 식별자

이성체 SMILES

C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)/C=C(/C3=CN=CN=C3)\C(=O)N

PubChem CID

117763569

분자량

428.29

화학 및 물리적 특성

• 용해성: DMSO : 50 mg/mL (116.74 mM; Need ultrasonic)
• 분자량: 428.290 g/mol
• XLogP3: 2.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 4
• Exact Mass: 428.082 Da
• Monoisotopic Mass: 428.082 Da
• Topological Polar Surface Area: 99.600 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 626.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1