Emricasan (IDN-6556) - Moligand™, 10mM in DMSO , Caspase inhibitor, CAS No.254750-02-2, Caspase inhibitor

CAS: 254750-02-2 Cat. No.: E409139 분자식: C₂₆H₂₇F₄N₃O₇ 분자량: 569.51

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PF 03491390, PF-03491390 | L-​Alaninamide, N-​[2-​(1,​1-​dimethylethyl)​phenyl]​-​2-​oxoglycyl-​N-​[(1S)​-​1-​(carboxymethyl)​-​2-​oxo-​3-​(2,​3,​5,​6-​tetrafluorophenoxy)​propyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.
In vitro

Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.

In vivo

Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.
Cell Data

cell lines：

Concentrations：9 μM

Incubation Time：1 h

Powder Purity:≥98%

Specifications

동의어

PF 03491390, PF-03491390 | L-​Alaninamide, N-​[2-​(1,​1-​dimethylethyl)​phenyl]​-​2-​oxoglycyl-​N-​[(1S)​-​1-​(carboxymethyl)​-​2-​oxo-​3-​(2,​3,​5,​6-​tetrafluorophenoxy)​propyl]​-

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Caspase inhibitor

제품 특성

ALogP

3.6

이름과 식별자

이성체 SMILES

C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C

분자량

569.51

Reaxy-Rn

10047524

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10047524&ln=

관련 대상(인간)

CASP8 Tchem Caspase-8 (1 Activities)

Discover Target: CASP8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CASP3 Tchem Caspase-3 (1 Activities)

Discover Target: CASP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 100 mg/mL (164.03 mM); Water: Insoluble; Ethanol: Insoluble