Name: (-)-Epicatechin - Moligand™, ≥97%(HPLC) , CAS No.490-46-0
Brand: Aladdin Scientific
SKU: E130023
Availability: InStock

개요 사양 이름과 식별자 문서 고급 데이터 Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 자주 묻는 질문과 기사 Citations of This Product 솔루션 계산기 리뷰

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이 등급을 선택하는 이유

Moligand™, ≥97%(HPLC) Moligand™ 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.

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보관 및 배송

Store at 2-8°C,Argon charged Wet ice 출고. 정확한 사양은 로트별 COA를 확인하세요.

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품질 문서

SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.

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문헌적 근거

크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 143편에서 인용되었습니다.

개요

Epicatechin is a flavanol. Cacao products are rich in epicatechin. Epicatechin enhances the skeletal muscle structure in heart failure patients and minimises the cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth.
Antioxidant found in chocolate.

Product description：

(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

Application：

(−)-Epicatechin (EC) has been used:

as an antioxidant to downregulate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase and improve insulin sensitivity in in vivo (high fat-fed mice) and in vitro (HepG2 cells) studies

to study its effect on blood pressure, nitric oxide synthase (NOS) activity and anxiety-like behavior on borderline hypertensive rat (BHR) models

to test its effect on neuronal survival in the hippocampus of middle-aged rats on swimming training, under oxidative stress

to study its antioxidant activity in dark chocolate

as a characteristic compound in polyphenols analysis

사양

동의어

사양 및 순도

Moligand™, ≥97%(HPLC)

생화학 및 생리적 메커니즘

Epicatechin enhances the skeletal muscle structure in heart failure patients and minimizes cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth

출처

Tea

보관 조건

Store at 2-8°C,Argon charged

배송

Wet ice

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

순수함

≥97%(HPLC)

이름과 식별자

Pubchem Sid

488184683

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488184683

정식 스마일

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

IUPAC Name

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol

InChIKey

PFTAWBLQPZVEMU-UKRRQHHQSA-N

INCHI

1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1

이성체 SMILES

C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

WGK 독일

RTECS

KB3745000

대체 CAS

490-46-0,17334-50-8

MeSH 용어

(+)-Catechin;(+)-Cyanidanol;(+)-Cyanidanol-3;(-)-Epicatechin;(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol;2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-cis)-;3,3',4',5,7-Flavanpentol;Catechin;Catechinic Acid;Catechuic Acid;

분자량

290.27

Beilstein

92760

Reaxy-Rn

6069926

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6069926&ln=

문서

📋 안전 데이터 시트(SDS)

위험성, 취급, 보관 및 규제 준수를 포괄하는 종합 문서.

<<<<<<< HEAD SDS 다운로드 → ======= SDS 다운로드 → >>>>>>> release248-p3

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고급 데이터

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - 분류 Flavonoids
    - Subclass Flavans
      - Level5 Flavan-3-ols
        Level6 Catechins

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
분류	Flavonoids
Subclass	Flavans
Intermediate Tree Nodes	Flavan-3-ols
Direct Parent	Catechins
Alternative Parents	7-hydroxyflavonoids 5-hydroxyflavonoids 4'-hydroxyflavonoids 3-hydroxyflavonoids 3'-hydroxyflavonoids 1-benzopyrans Catechols Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Secondary alcohols Polyols Oxacyclic compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Catechin - 3'-hydroxyflavonoid - 3-hydroxyflavonoid - 4'-hydroxyflavonoid - 5-hydroxyflavonoid - 7-hydroxyflavonoid - Hydroxyflavonoid - Chromane - Benzopyran - 1-benzopyran - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Phenol - Benzenoid - Monocyclic benzene moiety - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Polyol - Ether - Organic oxygen compound - Alcohol - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
설명	This compound belongs to the class of organic compounds known as catechins. These are compounds containing a catechin moiety, which is a 3,4-dihydro-2-chromene-3,5.7-tiol.
External Descriptors	Flavans, Flavanols and Leucoanthocyanidins
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D 구조

관련 대상(비인간)

pol Human immunodeficiency virus type 1 protease (9113 Activities)

Discover Target: pol

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

blaZ Beta-lactamase (285 Activities)

Discover Target: blaZ

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTSL Cathepsin L (58 Activities)

Discover Target: CTSL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Galc Galactocerebrosidase (11 Activities)

Discover Target: Galc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

Discover Target: Pkm

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Iap Intestinal alkaline phosphatase (419 Activities)

Discover Target: Iap

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Salmonella paratyphi (588 Activities)

Lot Number	Certificate Type	날짜	항목
J2610405	Certificate of Analysis	Sep 21, 2026	E130023
J2610404	Certificate of Analysis	Sep 21, 2026	E130023
J2610403	Certificate of Analysis	Sep 21, 2026	E130023
J2610346	Certificate of Analysis	Sep 21, 2026	E130023
J2610345	Certificate of Analysis	Sep 21, 2026	E130023
K2203379	Certificate of Analysis	Jul 30, 2026	E130023
D2622424	Certificate of Analysis	Mar 09, 2026	E130023
D2622395	Certificate of Analysis	Mar 09, 2026	E130023
D2622392	Certificate of Analysis	Mar 09, 2026	E130023
I2602100	Certificate of Analysis	Mar 09, 2026	E130023
I2516248	Certificate of Analysis	Jul 19, 2025	E130023
I2516246	Certificate of Analysis	Jul 19, 2025	E130023
I2516241	Certificate of Analysis	Jul 19, 2025	E130023
I2516249	Certificate of Analysis	Jul 19, 2025	E130023
I2516250	Certificate of Analysis	Jul 19, 2025	E130023
I2516251	Certificate of Analysis	Jul 19, 2025	E130023
C2605142	Certificate of Analysis	Jul 19, 2025	E130023
E2507168	Certificate of Analysis	Apr 21, 2025	E130023
E2507169	Certificate of Analysis	Apr 21, 2025	E130023
E2507170	Certificate of Analysis	Apr 21, 2025	E130023
E2507171	Certificate of Analysis	Apr 21, 2025	E130023
E2507172	Certificate of Analysis	Apr 21, 2025	E130023
J2425451	Certificate of Analysis	Sep 23, 2024	E130023
J2425452	Certificate of Analysis	Sep 23, 2024	E130023
J2425453	Certificate of Analysis	Sep 23, 2024	E130023
J2425454	Certificate of Analysis	Sep 23, 2024	E130023
J2412077	Certificate of Analysis	Mar 18, 2024	E130023
C2430071	Certificate of Analysis	Mar 18, 2024	E130023
C2430072	Certificate of Analysis	Mar 18, 2024	E130023
C2430073	Certificate of Analysis	Mar 18, 2024	E130023
C2430074	Certificate of Analysis	Mar 18, 2024	E130023
C2430075	Certificate of Analysis	Mar 18, 2024	E130023
L2327055	Certificate of Analysis	Nov 26, 2022	E130023
D2314453	Certificate of Analysis	Nov 26, 2022	E130023
L2315046	Certificate of Analysis	Nov 26, 2022	E130023
D23131134	Certificate of Analysis	Nov 26, 2022	E130023
D23131165	Certificate of Analysis	Nov 26, 2022	E130023
D23131190	Certificate of Analysis	Nov 26, 2022	E130023
D23131208	Certificate of Analysis	Nov 26, 2022	E130023
D2314022	Certificate of Analysis	Nov 26, 2022	E130023
D2314023	Certificate of Analysis	Nov 26, 2022	E130023
D2314128	Certificate of Analysis	Nov 26, 2022	E130023
D2314142	Certificate of Analysis	Nov 26, 2022	E130023
D2314143	Certificate of Analysis	Nov 26, 2022	E130023
K2203380	Certificate of Analysis	Nov 12, 2022	E130023
K2203382	Certificate of Analysis	Nov 12, 2022	E130023
K2203383	Certificate of Analysis	Nov 12, 2022	E130023
K2203384	Certificate of Analysis	Nov 12, 2022	E130023
K2203381	Certificate of Analysis	Oct 26, 2022	E130023
C2215299	Certificate of Analysis	Mar 19, 2022	E130023

용해성	Soluble in acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly)., Soluble in acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly).,
감도	heat & air sensitive
특정 회전[α]	-62° (C=0.1,MeOH)
녹는점(°C)	240°C
분자량	290.270 g/mol
XLogP3	0.400
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	1
Exact Mass	290.079 Da
Monoisotopic Mass	290.079 Da
Topological Polar Surface Area	110.000 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	364.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

(-)-Epicatechin - Moligand™, ≥97%(HPLC) , CAS No.490-46-0

보관 및 배송

품질 문서

문헌적 근거

개요

사양

문서

📋 안전 데이터 시트(SDS)

✅ 분석 성적서(COA)

📊 데이터시트

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고급 데이터

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