Epothilone A - 10mM in DMSO , CAS No.152044-53-6

CAS: 152044-53-6 Cat. No.: E409291 분자식: C₂₆H₃₉NO₆S 분자량: 493.66

등급 & 순도 10mM in DMSO

Synonyms

(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Epothilone A Epothilone A is a paclitaxel-like microtubule -stabilizing agent with EC 0.01 of 2 μM.
In vitro

Epothilone A, discovered from the myxobacterium Sorangium cellulosum, is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis.Epothilone A potently inhibits cell proliferation in HCT116 cells, with IC50 of 4.4 nM. Epothilone A also displays cytotoxicity in KB3-1, KBV-1, Hela, and Hs578T cells, with IC50 values ranging from 13 nM to 160 nM. Epothilone A is more water soluble than Taxol and competes with Taxol in binding with microtubules, with IC50 of 2.3 μM. However, both Epothilone A and Taxol don\'t share a common pharmacophore and exploits the tubulin-binding pocket uniquely and independently. Recently, it is found that microbiological transformation of Epothilone A by Aspergillus niger AS 3.739 yields several metabolites that is also toxic to MCF-7 cells, but with much higher IC50 values.

In vivo

Cell Data

cell lines：A431, MO7e, HUVEC and NHDF cells

Concentrations：0–2 μM

Incubation Time：24 hours for mitotic arrest or 72 hours for cytotoxicity

Powder Purity:≥98%

사양

동의어

(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC_0.01 of 2 μM.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

C[C@H]1CCC[C@@H]2[C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C

WGK 독일

3

분자량

493.66

Reaxy-Rn

26220988

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26220988&ln=