ERK1/2 inhibitor 1 - 10mM in DMSO , CAS No.2095719-90-5

CAS: 2095719-90-5 Cat. No.: E656204 분자식: C₂₉H₃₂ClN₅O₄ 분자량: 550.05 PubChem CID: 129053491

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1 / 2 inhibitor, showing 60% inhibition at 1 nM and an IC 50 of 3.0 nM against ERK1 and ERK2 , respectively

In Vitro

ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC 50 s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:ERK2 3.0 nM (IC 50 ) ERK1

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1 / 2 inhibitor, showing 60% inhibition at 1 nM and an IC 50 of 3.0 nM against ERK1 and ERK2 , respectively.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

• 이성체 SMILES: CC1=CC(=CC=C1)[C@@H](CO)NC(=O)[C@@H](C)N2CC3=C(C2=O)C=C(C=C3)C4=NC(=NC=C4Cl)NC5CCOCC5
• PubChem CID: 129053491
• 분자량: 550.05

관련 대상(인간)

MAPK1 Tchem Mitogen-activated protein kinase 1 (0 Activities)

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)