ES-072 , CAS No.2089721-94-6

CAS: 2089721-94-6 Cat. No.: E1434205 분자식: C₂₅H₂₇F₃N₈O₂ 분자량: 528.53

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

ES-072 is an orally effective selective EGFR mutant ( EGFR-T790M ) inhibitor. ES-072 activates GSK3α by inhibiting EGFR-T790M activity, which promotes phosphorylation of PD-L1 at Ser279 and Ser283. The phosphorylated PD-L1 recruits the E3 ubiquitin ligase ARIH1 , leading to ubiquitination and proteasomal degradation of PD-L1. This mechanism not only reduces cancer cell growth but also enhances anti-tumor immune response by lowering PD-L1 levels. ES-072 can be used to inhibit proliferation in non-small cell lung cancer (NSCLC) cells.

Specifications

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

이름과 식별자

분자량

528.53