Ethynodiol diacetate - Moligand™, 10mM in DMSO , Progesterone receptor agonist, CAS No.297-76-7, Progesterone receptor agonist

CAS: 297-76-7 Cat. No.: E408955 분자식: C₂₄H₃₂O₄ 분자량: 384.51 EC 번호: 206-044-9

등급 & 순도 Moligand™, 10mM in DMSO

Synonyms

8080 CB | 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Ethynodiol diacetate (8080 CB) is one of the first synthetic progestogens used in contraceptive pills.
In vitro

Nordihydroguaiaretic acid (NDGA) (< 1.5 μM) decreases the percentage of sister chronnatid exchanges (SCEs) in human lymphocyte culture treated with ethynodiol diacetate (150 μg/mL). Since the NDGA treatment, in the presence of S9 mix, reduce the genotoxic damage by ethynodiol diacetate, the reduction may be due to the inhibition of cytochrome P450s which prevents the metabolic activation of ethynodiol diacetate or NDGA may act as a free radical scavenger. Ethynodiol diacetate (150 μg/mL) increases sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) frequencies and inhibits lymphocyte proliferation in the presence of S9 mix in human lymphocyte.

In vivo

Ethynodiol diacetate (6 mg/kg b.w. daily) significantly increases the amounts of excreted 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in urine in female rats. Significant increase in the weights of pituitary, liver and kidneys are noted in rats treated with ethynodiol diacetate (6 mg/kg b.w. daily). Norgestrel (75 μg/day) and ethynodiol diacetate (150 μg/day), co-administered with ethinyl estradiol (7.5 μg/day), lowers the plasma concentrations of HDL cholesterol in cynomolgus monkeys.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

사양

동의어

8080 CB | 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Ethynodiol diacetate (8080 CB) is one of the first synthetic progestogens used in contraceptive pills.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

AGONIST

작동 메커니즘

Progesterone receptor agonist

제품 특성

ALogP

3.9

이름과 식별자

이성체 SMILES

CC(=O)O[C@H]1CC[C@@H]2[C@H]3CC[C@]4([C@H]([C@@H]3CCC2=C1)CC[C@]4(C#C)OC(=O)C)C

WGK 독일

3

RTECS

RC8963000

분자량

384.51

Reaxy-Rn

2678817

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2678817&ln=

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 30 mg/mL (195.89 mM); Water: Insoluble; Ethanol: Insoluble
• 특정 회전[α]: -72° (C=1,CHCl3)
• 녹는점(°C): 130 °C