Evenamide - ≥97% , Sodium channel alpha subunit blocker, CAS No.1092977-61-1, Sodium channel alpha subunit blocker

CAS: 1092977-61-1 Cat. No.: E650151 분자식: C₁₆H₂₆N₂O₂ 분자량: 278.39 PubChem CID: 25105689

등급 & 순도 ≥97%

Synonyms

HY-17612 | Evenamide | 2-((3-Butoxyphenethyl)amino)-N,N-dimethylacetamide | DTXSID101032897 | F50592 | Evenamide [INN] | US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N,N-dimethylacetamide | Q21098995 | UNII-ON5S6N53JS | AS-48527 | Acetamide, 2-((2-(3-buto

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.

사양

동의어

HY-17612 | Evenamide | 2-((3-Butoxyphenethyl)amino)-N,N-dimethylacetamide | DTXSID101032897 | F50592 | Evenamide [INN] | US9051240, 2-[2-(3-Butoxyphenyl)-ethylamino]-N,N-dimethylacetamide | Q21098995 | UNII-ON5S6N53JS | AS-48527 | Acetamide, 2-((2-(3-buto

사양 및 순도

≥97%

생화학 및 생리적 메커니즘

Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker ( K i =0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness

보관 조건

Protected from light,Store at -20°C

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

작업 유형

BLOCKER

작동 메커니즘

Sodium channel alpha subunit blocker

순수함

≥97%

제품 특성

ALogP

2.5

이름과 식별자

Pubchem Sid

528764434

정식 스마일

CCCCOC1=CC=CC(=C1)CCNCC(=O)N(C)C

IUPAC Name

2-[2-(3-butoxyphenyl)ethylamino]-N,N-dimethylacetamide

InChIKey

GRHBODILPPXVKN-UHFFFAOYSA-N

INCHI

1S/C16H26N2O2/c1-4-5-11-20-15-8-6-7-14(12-15)9-10-17-13-16(19)18(2)3/h6-8,12,17H,4-5,9-11,13H2,1-3H3

이성체 SMILES

CCCCOC1=CC=CC(=C1)CCNCC(=O)N(C)C

대체 CAS

1092977-61-1

PubChem CID

25105689

분자량

278.39

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 분류 Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acid amides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 분류: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Alpha amino acid amides
• Alternative Parents: Phenethylamines Phenoxy compounds Phenol ethers Aralkylamines Alkyl aryl ethers Tertiary carboxylic acid amides Dialkylamines Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Alpha-amino acid amide - Phenethylamine - Phenoxy compound - Phenol ether - Alkyl aryl ether - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Tertiary carboxylic acid amide - Carboxamide group - Secondary amine - Ether - Secondary aliphatic amine - Organic oxide - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Amine - Organic nitrogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

MAOB Tclin Monoamine oxidase B (8835 Activities)

Discover Target: MAOB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (359.21 mM; Need ultrasonic)
• 감도: Light sensitive
• 분자량: 278.390 g/mol
• XLogP3: 2.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 278.199 Da
• Monoisotopic Mass: 278.199 Da
• Topological Polar Surface Area: 41.600 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 269.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1