Chlorindanol: Properties, Safety & Laboratory Use Guide

Chlorindanol is a chlorinated indanol derivative recognized in research settings for its antimicrobial properties and used as a reference compound or active ingredient in pharmaceutical and biological studies.

Chemical Name

5-Chloro-2,3-dihydro-1H-inden-1-ol (Chlorindanol)

SKU / Catalog Number

C647171

Molecular Formula

C9H9ClO

Compound Class

Halogenated indanol; phenolic alcohol derivative

Primary Research Use

Antimicrobial studies, pharmaceutical reference standard

Cross-Reference

MCE: HY-B0999

Storage Recommendation

Store according to SDS instructions; typically cool, dry, away from light

Chemical Identity and Physical Properties

Chlorindanol (SKU: C647171; MCE cross-reference HY-B0999) is a halogenated derivative of indanol, systematically named 5-chloro-2,3-dihydro-1H-inden-1-ol. Its molecular formula is C₉H₉ClO, incorporating a bicyclic indane skeleton with a hydroxyl group at the 1-position and a chlorine substituent at the 5-position of the aromatic ring.

The compound is classified as a phenolic alcohol and belongs to the broader family of halogenated aromatic compounds. Its chlorinated phenolic character imparts a degree of surface activity and biological reactivity that underpins its antimicrobial profile. Physical properties such as exact melting point, boiling point, and solubility should be verified against the current Certificate of Analysis (CoA) and Safety Data Sheet (SDS) provided by Aladdin Scientific at the time of purchase, as these values can vary with purity grade.

Chlorindanol is typically a white to off-white solid at room temperature. It exhibits limited water solubility but may dissolve in common organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF). Researchers should prepare fresh stock solutions and verify solubility empirically for each application.

Mechanism of Action and Research Applications

Chlorindanol has been studied primarily for its antimicrobial activity. The chlorinated phenolic hydroxyl moiety is widely associated with disruption of microbial cell membranes and interference with essential enzymatic processes in bacteria and fungi, a mechanism common to halogenated phenols. However, specific mechanistic data for Chlorindanol should be validated against primary peer-reviewed literature before being cited in publications.

In pharmaceutical research, Chlorindanol has been historically investigated as a topical antiseptic and antifungal agent. It has appeared in formulations targeting dermatophytes and other superficial pathogens. Researchers may employ it as an active pharmaceutical ingredient (API) reference standard or as a positive control in antimicrobial susceptibility assays.

Additional research applications may include:

• Structure–activity relationship (SAR) studies: Chlorindanol serves as a scaffold for synthesizing novel halogenated indanol analogs with optimized bioactivity profiles.
• In vitro cell-based assays: Assessment of cytotoxicity, selectivity indices, and membrane permeability effects.
• Pharmaceutical formulation research: Evaluation of stability, compatibility, and delivery vehicle optimization.

Researchers should consult current literature and the supplier's technical documentation to confirm the suitability of Chlorindanol for their specific experimental models.

Safe Handling, Storage, and Disposal Guidelines

As with all research-grade chemical reagents, Chlorindanol must be handled in accordance with good laboratory practice (GLP) and all applicable local regulations. Researchers and lab managers should obtain and review the current Safety Data Sheet (SDS) for C647171 prior to use.

Personal Protective Equipment (PPE): Wear appropriate PPE at all times, including chemical-resistant gloves (nitrile recommended), laboratory coat, and safety goggles. Where dust or aerosol generation is possible, use a fume hood or respiratory protection compliant with local occupational health standards.

Storage: Store Chlorindanol in a tightly sealed container in a cool, dry, well-ventilated area, away from direct light, heat sources, and incompatible materials (e.g., strong oxidizers, strong bases). Refer to the SDS for specific temperature and humidity requirements. Maintain the compound away from food, drink, and animal feed.

Spill Management: In case of a spill, avoid generating dust. Collect the material using inert absorbent (e.g., dry sand or vermiculite), place in a labeled waste container, and dispose of according to local hazardous waste regulations.

Disposal: Do not discharge Chlorindanol into sewage systems or water bodies. Dispose of as chemical waste in compliance with institutional environmental health and safety (EHS) policies and relevant national and regional regulations.

Note: The specific hazard classification of Chlorindanol should be confirmed from the official SDS supplied with the product. The above represents general best-practice guidance for organic halogenated compounds.

Preparation of Stock Solutions and Quality Considerations

When preparing stock solutions of Chlorindanol for in vitro or in vivo research, the following procedural recommendations apply:

1. Solvent selection: DMSO is commonly used as a primary solvent for hydrophobic aromatic compounds. Prepare a concentrated stock (e.g., 10–100 mM) and dilute into aqueous buffer or culture medium immediately before use. Ensure the final DMSO concentration in assay wells does not exceed cytotoxicity thresholds (typically ≤0.1% v/v for cell-based assays, though this should be empirically validated).
2. Weighing: Allow the compound container to equilibrate to room temperature before opening to prevent moisture condensation on the solid. Use an analytical balance with appropriate precision.
3. Sterile filtration: For cell culture applications, filter stock solutions through a 0.22 µm membrane filter after preparation.
4. Stability: Prepare aliquots to minimize freeze–thaw cycles. Store aliquots as recommended in the SDS. Monitor solutions for precipitation or discoloration as indicators of degradation.
5. Purity verification: Review the Certificate of Analysis (CoA) supplied with each lot. For critical applications, consider independent purity verification by HPLC or NMR.

Aladdin Scientific provides lot-specific CoA documentation for C647171. Contact technical support or your account manager for additional analytical data if required.

Ordering, Procurement, and Customer Support

Chlorindanol is available from Aladdin Scientific under catalog number C647171. Researchers and procurement personnel should note the following when placing orders:

• Quote and pricing: Contact your Aladdin Scientific account representative or submit an inquiry through the official website for current pricing, volume discounts, and lead times. Prices and promotional offers may vary and are subject to change.
• Minimum order quantities: Check the current product listing for available pack sizes. Custom quantities may be available upon request.
• Shipping and storage during transit: Chlorindanol will be shipped under conditions appropriate to its stability requirements. Review the SDS and CoA upon receipt and report any discrepancies or damage to Aladdin Scientific customer service immediately.
• Returns and refunds: Aladdin Scientific's standard return and refund policy applies. Products must be returned in original, unopened condition unless a quality issue is identified. Contact customer service within the specified notification window detailed in Aladdin's terms and conditions.
• Regulatory documentation: For import/export, institutional procurement, or regulatory compliance purposes, Aladdin Scientific can provide SDS, CoA, and other supporting documentation upon request.

For technical inquiries regarding Chlorindanol applications, experimental design, or compatibility, Aladdin Scientific's technical support team is available via the official contact channels listed on the website.

Frequently asked questions

What is Chlorindanol used for in research?

Chlorindanol is primarily investigated for its antimicrobial properties, including antifungal and antibacterial activity. It is used as a reference standard in pharmaceutical research, as a positive control in antimicrobial assays, and as a synthetic scaffold for structure–activity relationship studies on halogenated indanol derivatives.

What solvents are recommended for dissolving Chlorindanol?

Chlorindanol has limited water solubility and is best dissolved in organic solvents such as DMSO, ethanol, or DMF. For biological assays, prepare a concentrated stock in DMSO and dilute into aqueous medium immediately before use, keeping the final DMSO concentration below cytotoxic levels (generally ≤0.1% v/v for cell-based assays, to be empirically confirmed).

How should Chlorindanol (C647171) be stored to maintain stability?

Chlorindanol should be stored in a tightly sealed container in a cool, dry, well-ventilated area, protected from direct light and heat. Specific temperature recommendations are provided in the Safety Data Sheet (SDS) and Certificate of Analysis (CoA) supplied with the product. Aliquoting stock solutions can minimize freeze–thaw degradation.

Where can I obtain the Safety Data Sheet (SDS) and Certificate of Analysis (CoA) for C647171?

The SDS and lot-specific CoA for Chlorindanol (C647171) are available from Aladdin Scientific. You can request these documents through the official Aladdin Scientific website or by contacting your account manager or customer service representative directly.

Is Chlorindanol the same compound as MCE HY-B0999?

Yes, the Aladdin Scientific product Chlorindanol (C647171) carries the cross-reference MCE catalog number HY-B0999, indicating these designations refer to the same chemical entity. Researchers should verify purity and specifications via the CoA for each specific lot before use.

References

1. Aladdin Scientific. Chlorindanol, Catalog No. C647171. Product Information and Safety Data Sheet. Aladdin Scientific.
2. MedChemExpress (MCE). Chlorindanol, Catalog No. HY-B0999. Product Information.
3. Textbook-level reference: March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. [General reference for halogenated phenolic compound properties and reactivity — specific edition and page numbers require verification.]

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.