Cathepsin K

Bone remodeling depends on the dynamic coupling between new bone formation by osteoblasts and old bone removal by osteoclasts. ALP, TRAP, Cathepsin K, and MMPs participate in the establishment of the mineralization environment, osteoclast maturation, collagen degradation, and matrix remodeling, ...

Cysteine endopeptidases are a class of proteases in which a catalytic cysteine residue participates in peptide bond hydrolysis. They include plant-derived proteolytic enzymes, lysosomal cathepsins, and endoproteases with specific cleavage-site preferences. Papain, ficin, and chymopapain are ...

Research on the cathepsin family is mainly used to elucidate mechanisms involving lysosomal proteolysis, antigen processing, cell death, matrix remodeling, and inflammatory responses. Members such as Cathepsin B, D, K, L, S, and G differ significantly in catalytic type, cellular localization, ...