Ganoderic acid D - 10mM in DMSO , CAS No.108340-60-9

CAS: 108340-60-9 Cat. No.: G654739 분자식: C₃₀H₄₂O₇ 분자량: 514.65 PubChem CID: 14109406

등급 & 순도 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum . Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3 . Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

In Vitro

Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC 50 of 17.3 mM.\nGanoderic acid D (1-50 μM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner. Ganoderic acid D (10, 50 μM; 24, 48 hours) induces G2/M phase arrest. Ganoderic acid D (10, 50 μM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells. Ganoderic acid D (10 μM; 48 hours) up-regulates 14-3-3E and PRDX3. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 1, 5, 10, 20, 50 μM Incubation Time: 24, 48, 72 hours Result: Reduced the cell survival rate in a dose- and time-dependent manner and had an IC 50 value of 17.3 μM for 48 hours treatment. Cell Cycle AnalysisCell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10, 50 μM Incubation Time: 24, 48 hours Result: Induced G2/M phase arrest. Displayed a cell cycle profile with an elevated G2/M cell population after 24-h treatment with 10 μM. Apoptosis AnalysisCell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10, 50 μM Incubation Time: 48 hours Result: Induced a morphological change typical of apoptosis in HeLa cells. Western Blot AnalysisCell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10 μM Incubation Time: 48 hours Result: Up-regulated 14-3-3E and PRDX3.

IC50& Target:SIRT3

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum . Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3 . Ganoderic acid D

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

C[C@H](CC(=O)CC(C)C(=O)O)[C@H]1CC(=O)[C@@]2([C@@]1(CC(=O)C3=C2[C@H](C[C@@H]4[C@@]3(CCC(=O)C4(C)C)C)O)C)C

PubChem CID

14109406

MeSH 용어

ganoderic acid D

분자량

514.65

관련 대상(인간)

TNF Tclin Tumor necrosis factor (1 Activities)

Discover Target: TNF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 108340-60-9, the molecular formula is C30H42O7, and the molecular weight is 514.65 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.