GLPG1205 - 10mM in DMSO , CAS No.1445847-37-9

CAS: 1445847-37-9 Cat. No.: G654943 분자식: C₂₂H₂₂N₂O₄ 분자량: 378.42 PubChem CID: 71616860

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis.

In Vitro

GLPG1205 (0.5 μM) completely inhibits the ZQ16-induced [Ca 2+ ]i response in neutrophils. GLPG1205 (1 μM; for 5 min) completely blocks the ROS-response induced by the GPR84-agonist. GLPG1205 can potently antagonizes ZQ16-induced ROS with an IC 50 value of 15 nM in TNF-α primed neutrophils. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GLPG1250 (orally adminstation; 30mg/kg; twice daily) for 2 weeks, starts from 7 days post-challenge,greatly reduces the Ashcroft score, in idiopathic pulmonary fibrosis model. GLPG1250 (orally adminstation; 30mg/kg; once daily) starts from 18 weeks post irradition, significantly reduces college deposition in the mouse lung. Additionlly, GLPG1250 inhibits the increase in MnSOD in lung bronchial epithelial cells and parenchymal macrophages, in the irradiation model. GLPG1205 dose dependently decreases disease activity, histological activity, neutrophil influx and colonic MPO content,in a mouse IBD model. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

ANTAGONIST

제품 특성

• ALogP: 2.4

이름과 식별자

• 이성체 SMILES: C1CC1C#CC2=CC3=C(C=C2)C4=CC(=NC(=O)N4CC3)OC[C@@H]5COCCO5
• PubChem CID: 71616860
• 분자량: 378.42

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1445847-37-9, the molecular formula is C22H22N2O4, and the molecular weight is 378.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.