Name: GNF-6231 - Moligand™, ≥98% , Inhibitor of porcupine O-acyltransferase, CAS No.1243245-18-2, Inhibitor of porcupine O-acyltransferase
SKU: G414093
Availability: InStock

GNF-6231 - Moligand™, ≥98% , Inhibitor of porcupine O-acyltransferase, CAS No.1243245-18-2, Inhibitor of porcupine O-acyltransferase

CAS: 1243245-18-2 Cat. No.: G414093 분자식: C₂₄H₂₅FN₆O₂ 분자량: 448.49

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GNF-6231 - Moligand™, ≥98% CAS No(1243245-18-2) by Aladdin Scientific

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주문 가능

GRADE & PURITY Moligand™ ? ≥98%

Synonyms

N-[5-(4-Acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl[2,4'-bipyridine]-5-acetamide

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요 Specifications 이름과 식별자 Documentation Advanced Data Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 솔루션 계산기 리뷰

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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

개요

Information

GNF-6231 GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.

Targets

Porcupine (Cell-free) 0.8 nM

In vitro

GNF-6231 shows a good solubility. It has no appreciable activities, at least up to 10 μM testing concentrations, for more than 200 off-targets, which include GPCRs, kinases, proteases, transporters, ion channels, and nuclear receptors. GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested (2C9, 2D6, 3A4). It shows high permeability in a Caco-2 human cell permeability assay with a possible efflux.

In vivo

GNF-6231 demonstrates excellent pathway inhibition and induces robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model. GNF-6231 is moderately bound to mouse, rat, dog, monkey, and human plasma proteins (88.0, 83.1, 90.9, 71.2, and 95%, respectively). It shows good oral bioavailability, ranging from 72 to 96% in preclinical species (mouse, rat, and dog) when dosed in solution formulations. GNF-6231 is expected to have minimal to marginal distribution to tissues compared to total body water following intravenous administration to mouse (Vss 0.57 L/kg), rat (Vss 0.70 L/kg), and dog (Vss 0.25 L/kg).

Cell Research(from reference)

Cell lines：TM3 Wnt-Luc cells and L-cell Wnt3A cells

Incubation Time：24 h

Specifications

동의어

N-[5-(4-Acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl[2,4'-bipyridine]-5-acetamide

사양 및 순도

Moligand™, ≥98%

생화학 및 생리적 메커니즘

GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.

보관 조건

Store at -20°C,Argon charged

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Inhibitor of porcupine O-acyltransferase

순수함

≥98%

이름과 식별자

Pubchem Sid	504770869
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770869
정식 스마일	CC1=CC(=CN=C1C2=CC(=NC=C2)F)CC(=O)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)C
IUPAC Name	N-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]-2-[6-(2-fluoropyridin-4-yl)-5-methylpyridin-3-yl]acetamide
InChIKey	AXXNRMISICMFNS-UHFFFAOYSA-N
INCHI	1S/C24H25FN6O2/c1-16-11-18(14-28-24(16)19-5-6-26-21(25)13-19)12-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11,13-15H,7-10,12H2,1-2H3,(H,27,29,33)
이성체 SMILES	CC1=CC(=CN=C1C2=CC(=NC=C2)F)CC(=O)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)C
분자량	448.49
Reaxy-Rn	20663882
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20663882&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 분류 Diazinanes
    - Subclass Piperazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
분류	Diazinanes
Subclass	Piperazines
Intermediate Tree Nodes	Not available
Direct Parent	Pyridinylpiperazines
Alternative Parents	Bipyridines and oligopyridines N-arylpiperazines Dialkylarylamines N-arylamides 2-halopyridines Aminopyridines and derivatives Methylpyridines Aryl fluorides Imidolactams Heteroaromatic compounds Tertiary carboxylic acid amides Acetamides Secondary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Organic oxides Carbonyl compounds Organofluorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Bipyridine - N-arylpiperazine - Pyridinylpiperazine - Dialkylarylamine - N-arylamide - Aminopyridine - 2-halopyridine - Methylpyridine - Aryl fluoride - Aryl halide - Pyridine - Imidolactam - Heteroaromatic compound - Acetamide - Tertiary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Tertiary amine - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organooxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
설명	This compound belongs to the class of organic compounds known as pyridinylpiperazines. These are compounds containing a pyridinylpiperazine skeleton, which consists of a pyridine linked (not fused) to a piperazine by a bond by a single bond that is not part of a ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D 구조

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리뷰

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Lot Number	Certificate Type	날짜	항목
H2631119	Certificate of Analysis	Sep 14, 2026	G414093
B2521122	Certificate of Analysis	Nov 30, 2022	G414093
C23081412	Certificate of Analysis	Nov 30, 2022	G414093
C23081436	Certificate of Analysis	Nov 30, 2022	G414093
C23081442	Certificate of Analysis	Nov 30, 2022	G414093
C23081446	Certificate of Analysis	Nov 30, 2022	G414093
C23081449	Certificate of Analysis	Nov 30, 2022	G414093
I2501024	Certificate of Analysis	Nov 30, 2022	G414093

용해성	Solubility (25°C) In vitro DMSO: 89 mg/mL (198.44 mM); Ethanol: 5 mg/mL (11.14 mM); Water: Insoluble;
분자량	448.500 g/mol
XLogP3	1.700
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	448.202 Da
Monoisotopic Mass	448.202 Da
Topological Polar Surface Area	91.300 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	673.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1