GSK598809 - 10mM in DMSO , CAS No.863680-45-9

CAS: 863680-45-9 Cat. No.: G656730 분자식: C₂₂H₂₃F₄N₅OS 분자량: 481.51 PubChem CID: 24743758

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pK i of 8.9.

In Vivo

Cocaine and GSK598809 each increases peak mean arterial blood pressure. Least square mean differences are significant for both doses of cocaine compared with its vehicle. Likewise, least square mean differences are significant for both doses of GSK598809 as compared with its vehicle. The experimental question of interest, that is, whether GSK598809 significantly increases cocaine effects on peak mean arterial blood pressure, is probed by a prior it tests on the means of the fitted regression model. The dose of 3 mg/kg GSK598809 significantly increases the pressor effects of 5.6 mg/kg cocaine and of 1.7 mg/kg cocaine . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:pKi: DRD3

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pK i of 8.9.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

작업 유형

ANTAGONIST

이름과 식별자

• 이성체 SMILES: CC1=C(OC=N1)C2=NN=C(N2C)SCCCN3CC4CC4(C3)C5=C(C=C(C=C5)C(F)(F)F)F
• PubChem CID: 24743758
• 분자량: 481.51

관련 대상(인간)

DRD3 Tclin D(3) dopamine receptor (2 Activities)

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (4 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 863680-45-9, the molecular formula is C22H23F4N5OS, and the molecular weight is 481.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.