HIOC - ≥98%(HPLC) , CAS No.314054-36-9

CAS: 314054-36-9 Cat. No.: H287399 분자식: C₁₆H₁₉N₃O₃ 분자량: 301.34

등급 & 순도 ≥98%(HPLC)

Synonyms

N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide|HIOC|N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)-2-oxo-3-piperidinecarboxamide|N-(2-(5-HYdroxy-1H-indol-3-yl)ethyl)-2-oxopiperidine-3-carboxamide|N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration

사양

동의어

N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide | HIOC | N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)-2-oxo-3-piperidinecarboxamide | N-(2-(5-HYdroxy-1H-indol-3-yl)ethyl)-2-oxopiperidine-3-carboxamide | N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide

사양 및 순도

≥98%(HPLC)

생화학 및 생리적 메커니즘

Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD)in vivo. Blood brain barrier and blood-retinal barrier penetrant.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥98%(HPLC)

이름과 식별자

정식 스마일

C1CC(C(=O)NC1)C(=O)NCCC2=CNC3=C2C=C(C=C3)O

IUPAC Name

N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide

InChIKey

ZIMKJLALTRLXJO-UHFFFAOYSA-N

INCHI

1S/C16H19N3O3/c20-11-3-4-14-13(8-11)10(9-19-14)5-7-18-16(22)12-2-1-6-17-15(12)21/h3-4,8-9,12,19-20H,1-2,5-7H2,(H,17,21)(H,18,22)

이성체 SMILES

C1CC(C(=O)NC1)C(=O)NCCC2=CNC3=C2C=C(C=C3)O

분자량

301.34

Reaxy-Rn

26247052

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26247052&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Indoles and derivatives
      • Subclass Tryptamines and derivatives
        • Level5 Serotonins
          • Level6 N-acylserotonins

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Indoles and derivatives
• Subclass: Tryptamines and derivatives
• Intermediate Tree Nodes: Serotonins
• Direct Parent: N-acylserotonins
• Alternative Parents: Hydroxyindoles 3-alkylindoles Piperidinecarboxamides Piperidinones Delta lactams 1-hydroxy-2-unsubstituted benzenoids Substituted pyrroles 1,3-dicarbonyl compounds Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-acylserotonin - Hydroxyindole - 3-alkylindole - Indole - 3-piperidinecarboxamide - Piperidinecarboxamide - Delta-lactam - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Piperidinone - Piperidine - Benzenoid - 1,3-dicarbonyl compound - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Lactam - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as n-acylserotonins. These are aromatic heterocyclic compounds containing a serotonin, in which the amine group is acylated.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

화학 및 물리적 특성

• 용해성: Solvent:DMSO, Max Conc. mg/mL: 30.13, Max Conc. mM: 100
• 감도: heat sensitive；Moisture sensitive
• 분자량: 301.340 g/mol
• XLogP3: 1.000
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 301.143 Da
• Monoisotopic Mass: 301.143 Da
• Topological Polar Surface Area: 94.200 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 429.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 314054-36-9, the molecular formula is C16H19N3O3, and the molecular weight is 301.34 g/mol. InChIKey ZIMKJLALTRLXJO-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.