HSD1590 - ≥99% , CAS No.2379279-96-4

CAS: 2379279-96-4 Cat. No.: H649101 분자식: C₂₀H₁₈BN₃O₃ 분자량: 359.19 PubChem CID: 139030519

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s<2 nM). HSD1590 displays low cytotoxicity

In Vitro

HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration. HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB-23 cells Concentration: 0.5-10 µM Incubation Time: 12-24 hours Result: Exhibited approximately 80% viability at 12 hours and yielded an overall viability of 63% at 24 h.

Form:Solid

IC50& Target:ROCK1 1.22 nM (IC 50 ) ROCK2 0.51 nM (IC 50 )

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s<2 nM). HSD1590 displays low cytotoxicity.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

• 정식 스마일: B(C1=C(C(=CC=C1)C2=NC3=C(C4=C2CCC4)C5=C(C=C3)NN=C5)OC)(O)O
• IUPAC Name: [2-methoxy-3-(4,5,10-triazatetracyclo[7.7.0.02,6.012,16]hexadeca-1(9),2(6),3,7,10,12(16)-hexaen-11-yl)phenyl]boronic acid
• InChIKey: WTZMCUOBQPTERK-UHFFFAOYSA-N
• INCHI: 1S/C20H18BN3O3/c1-27-20-13(6-3-7-15(20)21(25)26)19-12-5-2-4-11(12)18-14-10-22-24-16(14)8-9-17(18)23-19/h3,6-10,25-26H,2,4-5H2,1H3,(H,22,24)
• 이성체 SMILES: B(C1=C(C(=CC=C1)C2=NC3=C(C4=C2CCC4)C5=C(C=C3)NN=C5)OC)(O)O
• PubChem CID: 139030519
• 분자량: 359.19

관련 대상(인간)

ROCK2 Tclin Rho-associated protein kinase 2 (2 Activities)

Discover Target: ROCK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK1 Tclin Rho-associated protein kinase 1 (2 Activities)

Discover Target: ROCK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK1 Tclin Rho-associated protein kinase 1 (4723 Activities)

Discover Target: ROCK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ROCK2 Tclin Rho-associated protein kinase 2 (6206 Activities)

Discover Target: ROCK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (278.40 mM; Need ultrasonic)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2379279-96-4, the molecular formula is C20H18BN3O3, and the molecular weight is 359.19 g/mol. InChIKey WTZMCUOBQPTERK-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.