HSK0935 - 10mM in DMSO , CAS No.1638851-44-1

CAS: 1638851-44-1 Cat. No.: H656288 분자식: C₂₂H₂₅ClO₇ 분자량: 436.88 PubChem CID: 86282875

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC 50 of 1.3 nM. Antihyperglycemic activities

In Vitro

HSK0935 (Compound 31) demonstrates excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HSK0935 treatment (1, 3, and 10 mg/kg) shows robust urinary glucose excretion in Sprague−Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys . HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 1.3 nM (SGLT2)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC 50 of 1.3 nM. Antihyperglycemic activities.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

• 이성체 SMILES: CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@@]34[C@@H]([C@H]([C@@H]([C@@](O3)(CO4)OC)O)O)O)Cl
• PubChem CID: 86282875
• 분자량: 436.88

관련 대상(인간)

SLC5A2 Tclin Sodium/glucose cotransporter 2 (1 Activities)

Discover Target: SLC5A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1638851-44-1, the molecular formula is C22H25ClO7, and the molecular weight is 436.88 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.