HUP30 - ≥99% , CAS No.312747-21-0

CAS: 312747-21-0 Cat. No.: H651067 분자식: C₁₄H₁₅N₃O₃S 분자량: 305.35 EC 번호: 808-920-1 PubChem CID: 739510

등급 & 순도 Moligand™, ≥99%

Synonyms

N-(6-nitrobenzo[d]thiazol-2-yl)cyclohexanecarboxamide | N-(6-Nitrobenzo[d]thiazol-2-yl) cyclohexane carboxaMide | N-(6-nitrobenzo[d]thiazol-2-yl) cyclohexanecarboxamide | Cyclohexanecarboxamide, N-(6-nitro-2-benzothiazolyl)- | HUP30 | N-(6-Nitro-2-benzoth

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

개요

HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K + channels, and blocks extracellular Ca 2+ influx.

In Vitro

HUP30 inhibits Phenylephrine-induced aorta contraction with an IC 50 value of 3.9 μM. HUP30 (100 μM) increases cGMP levels in Phenylephrine-stimulated aorta. HUP30 causes an antispasmodic effect on rat aorta rings contracted by 25/30 mM K + , with an IC 50 value of 7.5 μM. HUP30 (3-100 μM) inhibits both extracellular Ca 2+ influx and Ca 2+ mobilization induced by Phenylephrine. HUP30 (10-100 μM) inhibits the current in single tail artery myocytes.

Form:Solid

사양

동의어

N-(6-nitrobenzo[d]thiazol-2-yl)cyclohexanecarboxamide | N-(6-Nitrobenzo[d]thiazol-2-yl) cyclohexane carboxaMide | N-(6-nitrobenzo[d]thiazol-2-yl) cyclohexanecarboxamide | Cyclohexanecarboxamide, N-(6-nitro-2-benzothiazolyl)- | HUP30 | N-(6-Nitro-2-benzoth

사양 및 순도

Moligand™, ≥99%

생화학 및 생리적 메커니즘

HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K + channels, and blocks extracellular Ca 2+ influx.

보관 조건

Store at -20°C,Desiccated

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

INHIBITOR

순수함

≥99%

Product Line

H651067-5mg

이름과 식별자

정식 스마일

C1CCC(CC1)C(=O)NC2=NC3=C(S2)C=C(C=C3)[N+](=O)[O-]

IUPAC Name

N-(6-nitro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide

InChIKey

VMAKFFKOZSLHDW-UHFFFAOYSA-N

INCHI

1S/C14H15N3O3S/c18-13(9-4-2-1-3-5-9)16-14-15-11-7-6-10(17(19)20)8-12(11)21-14/h6-9H,1-5H2,(H,15,16,18)

이성체 SMILES

C1CCC(CC1)C(=O)NC2=NC3=C(S2)C=C(C=C3)[N+](=O)[O-]

WGK 독일

3

PubChem CID

739510

분자량

305.35

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Benzothiazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Benzothiazoles
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzothiazoles
• Alternative Parents: Nitroaromatic compounds N-arylamides Benzenoids Thiazoles Heteroaromatic compounds Secondary carboxylic acid amides Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Azacyclic compounds Organopnictogen compounds Organic zwitterions Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1,3-benzothiazole - Nitroaromatic compound - N-arylamide - Benzenoid - Azole - Heteroaromatic compound - Thiazole - Carboxamide group - C-nitro compound - Secondary carboxylic acid amide - Organic nitro compound - Carboxylic acid derivative - Organic oxoazanium - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organic zwitterion - Organopnictogen compound - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as benzothiazoles. These are organic compounds containing a benzene fused to a thiazole ring (a five-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (327.49 mM; ultrasonic and warming and heat to 50°C)
• 분자량: 305.350 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 305.083 Da
• Monoisotopic Mass: 305.083 Da
• Topological Polar Surface Area: 116.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 409.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 312747-21-0, the molecular formula is C14H15N3O3S, and the molecular weight is 305.35 g/mol. InChIKey VMAKFFKOZSLHDW-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.