IBR2 - Moligand™,10mM in DMSO , CAS No.313526-24-8

CAS: 313526-24-8 Cat. No.: I654536 분자식: C₂₄H₂₀N₂O₂S 분자량: 400.5 PubChem CID: 4664423

등급 & 순도 Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51 -mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis

In Vitro

IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC 50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC 50 of 14.8 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:RAD51

사양

사양 및 순도

Moligand™,10mM in DMSO

생화학 및 생리적 메커니즘

IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51 -mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis [1

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

이름과 식별자

이성체 SMILES

C1=CC=C(C=C1)CS(=O)(=O)N2C=CC3=CC=CC=C3C2C4=CNC5=CC=CC=C54

PubChem CID

4664423

분자량

400.5

자주 묻는 질문

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 313526-24-8, the molecular formula is C24H20N2O2S, and the molecular weight is 400.5 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.