iHCK-37 - 10mM in DMSO , CAS No.516478-09-4

CAS: 516478-09-4 Cat. No.: I654785 분자식: C₃₀H₃₂N₄O₂S₂ 분자량: 544.73

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a K i value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC 50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research

In Vitro

iHCK-37 (5.0-20 μM; 24 hours) exhibits a potent in vitro antiproliferative activity. The dose (μM) for growth inhibition (GI 50 ) is 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562). iHCK-37 (3-9 μM; plus Erythropoietin) leads to a decrease in ERK, AKT and P70S6K phosphorylation of in lentivirus HCK silenced K562 and U937 cell lines. iHCK-37 (3-9 μM) results in a decrease of p-HCK, p-ERK, p-AKT, p-70S6 in the cell line KG1a (AML/CD34 + ), in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: U937, HL60, KG1a, HEL and K562 cells Concentration: 5.0-20 μM Incubation Time: 24 hours Result: Exhibited a reduction of growth in a dose-dependent manner.

IC50& Target:Ki: 0.22 μM (Hck)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a K i value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC 50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 분자량: 544.73