Integrin modulator 1 - 10mM in DMSO , CAS No.2023788-32-9

CAS: 2023788-32-9 Cat. No.: I654526 분자식: C₁₃H₁₄N₂O₄ 분자량: 262.26 PubChem CID: 154734317

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC 50 of 9.8 nM for RGD-binding α4β1 . Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC 50 of 12.9 nM

In Vitro

Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion. Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells. Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:α4β1 9.8 nM (IC 50 )

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC 50 of 9.8 nM for RGD-binding α4β1 . Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC 50 of 12.9 nM.

보관 조건

Protected from light,Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

AGONIST

이름과 식별자

이성체 SMILES

CC1=CC=CC=C1NC(=O)N2C(CC2=O)CC(=O)O

PubChem CID

154734317

분자량

262.26