Ispronicline - 10mM in DMSO , Neuronal acetylcholine receptor; alpha4/beta2 partial agonist, CAS No.252870-53-4, Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

CAS: 252870-53-4 Cat. No.: I656837 분자식: C₁₄H₂₂N₂O 분자량: 234.34 PubChem CID: 9824145

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor ( nAChR ) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity ( K i =11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR.

In Vivo

Ispronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain .\nIspronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats weighting 180-200 g Dosage: 10 and 30 mg/kg Administration: s.c. Result: Induced c-Fos in medial paraventricular nucleus of hypothalamus. Treatment with 30 mg/kg ispronicline, but not 10 mg/kg, increased the number of c-Fos immunoreactive cells significantly as compared to controls within the medial parvocellular part of paraventricular nucleus (PVN).

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor ( nAChR ) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affi

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

PARTIAL AGONIST

작동 메커니즘

Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

제품 특성

• ALogP: 2.5

이름과 식별자

• 이성체 SMILES: C[C@@H](C/C=C/C1=CC(=CN=C1)OC(C)C)NC
• 대체 CAS: 252870-53-4
• PubChem CID: 9824145
• MeSH 용어: (S)-(E)-N-methyl-5-(3-(5-isopropoxypyridinyl))-4-penten-2-amine;AZD3480;ispronicline;N-methyl-5-(3-(5-isopropoxypyridinyl))-4-penten-2-amine;TC 1734;TC-1734;TC1734
• 분자량: 234.34

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 252870-53-4, the molecular formula is C14H22N2O, and the molecular weight is 234.34 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.