JGB1741 - ≥99% , CAS No.1256375-38-8

CAS: 1256375-38-8 Cat. No.: J649081 분자식: C₂₇H₂₄N₂O₂S 분자량: 440.56

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC 50 of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC 50 >100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research

In Vitro

JGB1741 (ILS-JGB-1741; 1-10000 nM; 24 h) inhibits MDA-MB 231 cell proliferation. JGB1741 (0.01-1 μM; 24 h) induces apoptosis of MDA-MB 231 cells. JGB1741 (0.01-1 μM; 24 h) shows a cell cycle arrest at G1 phase with more and more cells entering into sub G0/G1 phase. JGB1741 (0.01-1 μM; 24 h) shows an increase in the global acetylation of H3K9, p53 expression and acetylated p53K382 levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: K562, HepG2 and MDA-MB 231 cell lines Concentration: 1, 10, 50, 100, 500, 1000, 10000 nM Incubation Time: 24 hours Result: Inhibited MDA-MB 231 cell proliferation more potently with an IC 50 of 0.5 μM than K562 and HepG2 cell proliferation (IC 50 >1 μM). Apoptosis AnalysisCell Line: MDA-MB 231 cells Concentration: 0.01, 0.1, 0.5, 1 μM Incubation Time: Result: Showed an increase in the percent apoptotic cells in a dose-dependent fashion with ∼70% apoptosis at 1 μM concentration. Cell Cycle AnalysisCell Line: MDA-MB 231 cells Concentration: 0.01, 0.1, 0.5, 1 μM Incubation Time: Result: Showed a cell cycle arrest at G1 phase with more and more cells entering into sub G0/G1 phase, the apoptotic phase, in a dose-dependent fashion. Western Blot AnalysisCell Line: MDA-MB 231 cells Concentration: 0.01, 0.1, 0.5, 1 μM Incubation Time: Result: Caused a dose-dependent increase in the global acetylation of H3K9. Showed an increase in both p53 expression and acetylated p53K382 levels.

Form:Solid

IC50& Target:SIRT1 ∼15 μM (IC 50 ) SIRT2 >100 μM (IC 50 ) SIRT3 >100 μM (IC 50 )

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC 50 of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC 50 >100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with mod

보관 조건

Protected from light,Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

• 분자량: 440.56

화학 및 물리적 특성

• 용해성: DMSO : 5 mg/mL (11.35 mM; Need ultrasonic)

참고 문헌

1. Lanfeng Guo, Renlong Liu, Zhaobo He, Shaoping Li, Tong Tan, Changyuan Tao.  (2024)  Influence of PUB2 on the Leveling Effect of Chip Copper Connection Electroplating: Mechanism and Applications.  ACS Omega,      [PMID:38559988] [10.1021/acsomega.3c09548]

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1256375-38-8, the molecular formula is C27H24N2O2S, and the molecular weight is 440.56 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.