JI051 - ≥98% , CAS No.2234281-75-3

CAS: 2234281-75-3 Cat. No.: J648404 분자식: C₂₂H₂₄N₂O₃ 분자량: 364.44 PubChem CID: 138319697

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 ( PHB2 ), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.

In Vitro

JI051 causes G2/M cell-cycle arrest. JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC 50 of 0.3 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: HEK293 cells Concentration: 0.1-10 µM Incubation Time: 24 hours Result: Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.

Form:Solid

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 ( PHB2 ), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥98%

이름과 식별자

• 정식 스마일: CCOC1=CC=CC=C1CCNC(=O)C=CC2=CNC3=C2C=CC=C3OC
• IUPAC Name: (E)-N-[2-(2-ethoxyphenyl)ethyl]-3-(7-methoxy-1H-indol-3-yl)prop-2-enamide
• InChIKey: CQZPBIZGVIRKOC-VAWYXSNFSA-N
• INCHI: 1S/C22H24N2O3/c1-3-27-19-9-5-4-7-16(19)13-14-23-21(25)12-11-17-15-24-22-18(17)8-6-10-20(22)26-2/h4-12,15,24H,3,13-14H2,1-2H3,(H,23,25)/b12-11+
• PubChem CID: 138319697
• 분자량: 364.44

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Indoles and derivatives
      • Subclass Indoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Indoles and derivatives
• Subclass: Indoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Indoles
• Alternative Parents: Phenoxy compounds Anisoles Alkyl aryl ethers N-acyl amines Pyrroles Heteroaromatic compounds Carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indole - Phenoxy compound - Phenol ether - Anisole - Alkyl aryl ether - Benzenoid - N-acyl-amine - Monocyclic benzene moiety - Heteroaromatic compound - Pyrrole - Carboxamide group - Azacycle - Ether - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

화학 및 물리적 특성

• 용해성: DMSO : 125 mg/mL (342.99 mM; Need ultrasonic)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2234281-75-3, the molecular formula is C22H24N2O3, and the molecular weight is 364.44 g/mol. InChIKey CQZPBIZGVIRKOC-VAWYXSNFSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.