KH 7 - Moligand™, ≥98% , Inhibitor of adenylyl cyclase 10, CAS No.330676-02-3, Inhibitor of adenylyl cyclase 10

CAS: 330676-02-3 Cat. No.: K287947 분자식: C₁₇H₁₅BrN₄O₂S 분자량: 419.3 EC 번호: 633-023-5

GRADE & PURITY Moligand™, ≥98%

Synonyms

1613631-72-3 | ( inverted exclamation markA)-2-(1H-benziMidazol-2-ylthio)propanoicacid2-[(5-broMo-2-hydroxyphenyl)Methylene]hydrazide | HMS3648I20 | 2-(1H-benzimidazol-2-ylsulfanyl)-N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]propanamide | 2-(1H-benz

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

KH7 has been used: as a soluble adenyl cyclase (sAC) antagonist to study its effect on the signaling pathway mediated by the action of transient receptor type 1 (TRPV1) in sperm cells. as a selective sAC antagonist to study its effect on the signaling pathway of proton gated channels (HV1) induced action in sperm cells. as a sAC inhibitor to study its effects on cAMP increase in monophosphorylated myosin light chain (pMLC).

Specifications

동의어

1613631-72-3 | ( inverted exclamation markA)-2-(1H-benziMidazol-2-ylthio)propanoicacid2-[(5-broMo-2-hydroxyphenyl)Methylene]hydrazide | HMS3648I20 | 2-(1H-benzimidazol-2-ylsulfanyl)-N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]propanamide | 2-(1H-benz

사양 및 순도

Moligand™, ≥98%

생화학 및 생리적 메커니즘

KH7 is a selective inhibitor of soluble adenylyl cyclase. Soluble adenylyl cyclase (sAC) is an ubiquitously expressed, essential component of cAMP-signaling.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Inhibitor of adenylyl cyclase 10

순수함

≥98%

이름과 식별자

Pubchem Sid

504773360

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504773360

정식 스마일

CC(C(=O)NN=CC1=C(C=CC(=C1)Br)O)SC2=NC3=CC=CC=C3N2

IUPAC Name

2-(1H-benzimidazol-2-ylsulfanyl)-N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]propanamide

InChIKey

WILMXUAKQKGGCC-DJKKODMXSA-N

INCHI

1S/C17H15BrN4O2S/c1-10(25-17-20-13-4-2-3-5-14(13)21-17)16(24)22-19-9-11-8-12(18)6-7-15(11)23/h2-10,23H,1H3,(H,20,21)(H,22,24)/b19-9+

이성체 SMILES

CC(C(=O)N/N=C/C1=C(C=CC(=C1)Br)O)SC2=NC3=CC=CC=C3N2

분자량

419.3

Reaxy-Rn

22554258

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22554258&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Benzimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Benzimidazoles
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzimidazoles
• Alternative Parents: P-bromophenols Bromobenzenes Alkylarylthioethers 1-hydroxy-2-unsubstituted benzenoids Azines Aryl bromides Imidazoles Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organobromides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzimidazole - 4-halophenol - 4-bromophenol - Aryl thioether - Halobenzene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Bromobenzene - Alkylarylthioether - Benzenoid - Aryl halide - Aryl bromide - Monocyclic benzene moiety - Azine - Imidazole - Heteroaromatic compound - Azole - Azacycle - Sulfenyl compound - Thioether - Organooxygen compound - Organosulfur compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organonitrogen compound - Organohalogen compound - Organobromide - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

ADCY10 Tchem Adenylate cyclase type 10 (0 Activities)

Discover Target: ADCY10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solvent:DMSO, Max Conc. mg/mL: 41.93, Max Conc. mM: 100
• 분자량: 419.300 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 418.01 Da
• Monoisotopic Mass: 418.01 Da
• Topological Polar Surface Area: 116.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 495.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 330676-02-3, the molecular formula is C17H15BrN4O2S, and the molecular weight is 419.3 g/mol. InChIKey WILMXUAKQKGGCC-DJKKODMXSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.