KIF18A-IN-2 - ≥99% , CAS No.2600559-20-2

CAS: 2600559-20-2 Cat. No.: K650516 Molecular Weight: 534.69

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

KIF18A-IN-2 is a potent KIF18A inhibitor ( IC 50 =28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer

In Vivo

KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours . Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice . IP (100 mg/kg) C max (μM) 12.6 AUC 0-24 (μM·h) 147 C 24h (μM) 2.9 PPB (f u ) 0.007 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells) Dosage: 100 mg/kg Administration: i.p., single Result: Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.

Form:Solid

IC50& Target:IC 50 : 28 nM (KIF18A)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

KIF18A-IN-2 is a potent KIF18A inhibitor ( IC 50 =28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 534.69