KN-93 - Moligand™, 10mM in DMSO , Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit, CAS No.139298-40-1, Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit

CAS: 139298-40-1 Cat. No.: K421478 분자식: C₂₆H₂₉ClN₂O₄S 분자량: 599.03

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AMY3402 | (2-[N -(2-hydroxyethyl)]-N -(4-methoxybenzenesulfonyl)]amino-N -(4-chlorocinnamyl)-N -methylbenzylamine) | AKOS015994570 | BCP9000817 | J-007263 | NCGC00162399-02 | SCHEMBL14569460 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}me

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
An effective inhibitor of CaMKII phosphorylating activity

Specifications

동의어

AMY3402 | (2-[N -(2-hydroxyethyl)]-N -(4-methoxybenzenesulfonyl)]amino-N -(4-chlorocinnamyl)-N -methylbenzylamine) | AKOS015994570 | BCP9000817 | J-007263 | NCGC00162399-02 | SCHEMBL14569460 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}me

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to i

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit

이름과 식별자

• 이성체 SMILES: CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
• WGK 독일: 3
• 분자량: 599.03
• Reaxy-Rn: 8357363
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8357363&ln=

관련 대상(인간)

CAMK2A Tchem Calcium/calmodulin-dependent protein kinase type II subunit alpha (1 Activities)

Discover Target: CAMK2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 감도: Heat Sensitive
• 굴절률: 1.63
• 끓는점(°C): 657.60° C at 760 mmHg

참고 문헌

1. Jinpeng Lv, Ximei Zhang, Xiaohong An, Yan Cao, Duo Meng, Kun Zou, Rongyin Gao, Ruzhi Zhang.  (2023)  The inhibition of VDAC1 oligomerization promotes pigmentation through the CaMK–CRTCs/CREB–MITF pathway.  EXPERIMENTAL CELL RESEARCH,      [PMID:38070860] [10.1016/j.yexcr.2023.113874]

2. Yuqian Chen, Jin Liu, Qianqian Zhang, Limin Chai, Huan Chen, Danyang Li, Yan Wang, Yuanjie Qiu, Nirui Shen, Jia Zhang, Qingting Wang, Jian Wang, Xinming Xie, Shaojun Li, Manxiang Li.  (2024)  Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:38479721] [10.1016/j.ejphar.2024.176483]