Koumine - 10mM in DMSO , CAS No.1358-76-5

CAS: 1358-76-5 Cat. No.: K421364 분자식: C₂₀H₂₂N₂O 분자량: 306.4 EC 번호: 111-893-2

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Koumine can induce apoptosis of LoVo cells in a time-dependent manner and inhibit the DNA synthesis in LoVo cells, thereby blocking the cell cycle from G1 to S phase. Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has therapeutic effect against psoriasis, which is related to the inhibition of epidermal cell proliferation, promoting the formation of granular cells and decreasing the serum level of IL- Koumine can significantly reduce the damage to axon and myelin sheath of the sciatic nerve and increase sensory nerve conduction velocity , without affecting body weight and blood glucose, these findings encourage the use of koumine in the treatment of diabetic neuropathy. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. Koumine may produce anxiolytic-effect by increasing the levels of pregnenolone and allopregnenolone in hippocampus.

Specifications

사양 및 순도

10mM in DMSO

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

ACTIVATOR

제품 특성

• ALogP: 1.879
• hba_count: 2
• 회전 가능한 결합: 1

이름과 식별자

• Pubchem Sid: 528765089
• 정식 스마일: CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C
• IUPAC Name: (1R,10R,12S,15S,16R,17S)-15-ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene
• InChIKey: VTLYEMHGPMGUOT-FXWNUWCSSA-N
• INCHI: 1S/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/m0/s1
• 이성체 SMILES: CN1C[C@]2([C@@H]3C[C@@H]4C5=NC6=CC=CC=C6[C@]52C[C@H]1[C@H]3CO4)C=C
• 분자량: 306.4
• Reaxy-Rn: 25328208
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25328208&ln=

화학 및 물리적 특성

• DMSO(mg/mL) 최대 용해도: 15
• DMSO(mM) 최대 용해도: 48.9553771084918