10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Argon charged,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1) , is also a selective and potent a-site inhibitor of PDIA1 with an IC 50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family
In Vitro
KSC-34 is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins. KSC-34 contains a (4-phenylbutyl)methylamine diversity element for optimized binding to the active site of the a domain of PDIA1 with a chloroacetamide electrophile for covalent modification of C53 on PDIA1. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 3.5 μM (a active site of PDIA1), 104.5 μM (a′ active site of PDIA1)
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1) , is also a selective and potent a-site inhibitor of PDIA1 with an IC 50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for P
Storage
Argon charged, Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
PubChem CID
154573750
Molecular Weight
429.95
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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