KW-8232 - ≥98% , CAS No.217813-15-5

CAS: 217813-15-5 Cat. No.: K651007 분자식: C₃₇H₄₁ClN₄O₆S 분자량: 705.26 PubChem CID: 9853157

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

개요

KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2

In Vitro

KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE 2 in mouse osteoblastic cells. KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC 50 ~1.2 μM ). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: male Sprague-Dawley rats (5-week-old) . Dosage: 1, 3, 10, and 30 mg/kg. Administration: Orally once daily beginning 1 day prior to neurectomy for 28 days. Result: Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.

Form:Solid

IC50& Target:Prostaglandin Receptor

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.

보관 조건

Store at 2-8°C,Desiccated

배송

Wet ice

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작업 유형

INHIBITOR

순수함

≥98%

이름과 식별자

• 정식 스마일: CN(C)CCN1C2=CC=CC=C2C(=C1C(=O)N3CCN(CC3)C4=CC=CC=C4Cl)C(C5=CC=C(C=C5)O)C6=CC=C(C=C6)O.CS(=O)(=O)O
• IUPAC Name: [3-[bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]indol-2-yl]-[4-(2-chlorophenyl)piperazin-1-yl]methanone;methanesulfonic acid
• InChIKey: YBHZOINCWYRXCE-UHFFFAOYSA-N
• INCHI: 1S/C36H37ClN4O3.CH4O3S/c1-38(2)19-24-41-31-9-5-3-7-29(31)34(33(25-11-15-27(42)16-12-25)26-13-17-28(43)18-14-26)35(41)36(44)40-22-20-39(21-23-40)32-10-6-4-8-30(32)37;1-5(2,3)4/h3-18,33,42-43H,19-24H2,1-2H3;1H3,(H,2,3,4)
• 이성체 SMILES: CN(C)CCN1C2=CC=CC=C2C(=C1C(=O)N3CCN(CC3)C4=CC=CC=C4Cl)C(C5=CC=C(C=C5)O)C6=CC=C(C=C6)O.CS(=O)(=O)O
• PubChem CID: 9853157
• MeSH 용어: 3-(bis(4-hydroxyphenyl)methyl)-2-(4-(2-chlorophenyl)-piperazin-1-ylcarbonyl)-1-(2-dimethylaminoethyl)indole methanesulfonate;KW 8232;KW-8232
• 분자량: 705.26

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Phenylpiperazines N-arylpiperazines Indolecarboxamides and derivatives 3-alkylindoles N-alkylindoles 2-heteroaryl carboxamides Pyrrole carboxamides Aniline and substituted anilines Dialkylarylamines 1-hydroxy-2-unsubstituted benzenoids Chlorobenzenes Substituted pyrroles Aryl chlorides Tertiary carboxylic acid amides Sulfonyls Alkanesulfonic acids Organosulfonic acids Heteroaromatic compounds Methanesulfonates Amino acids and derivatives Trialkylamines Azacyclic compounds Organooxygen compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Not available
• Substituents: Diphenylmethane - Indolecarboxamide derivative - Indolecarboxylic acid derivative - Phenylpiperazine - N-arylpiperazine - N-alkylindole - 3-alkylindole - Indole or derivatives - Indole - Pyrrole-2-carboxylic acid or derivatives - Pyrrole-2-carboxamide - Tertiary aliphatic/aromatic amine - 2-heteroaryl carboxamide - Dialkylarylamine - Aniline or substituted anilines - Halobenzene - 1-hydroxy-2-unsubstituted benzenoid - Chlorobenzene - Phenol - Aryl halide - Piperazine - Aryl chloride - 1,4-diazinane - Substituted pyrrole - Heteroaromatic compound - Alkanesulfonic acid - Tertiary carboxylic acid amide - Methanesulfonate - Sulfonyl - Organosulfonic acid - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Pyrrole - Tertiary amine - Carboxamide group - Amino acid or derivatives - Tertiary aliphatic amine - Organoheterocyclic compound - Azacycle - Carboxylic acid derivative - Organochloride - Amine - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Organohalogen compound - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

화학 및 물리적 특성

• 용해성: DMSO : 125 mg/mL (177.24 mM; Need ultrasonic)

자주 묻는 질문

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 217813-15-5, the molecular formula is C37H41ClN4O6S, and the molecular weight is 705.26 g/mol. InChIKey YBHZOINCWYRXCE-UHFFFAOYSA-N.

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.