L-372662 - 10mM in DMSO , CAS No.162045-26-3

CAS: 162045-26-3 Cat. No.: L654535 분자식: C₃₃H₃₈N₄O₆ 분자량: 586.68 PubChem CID: 5311202

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

L-372662 is a potent and orally active non-peptide oxytocin antagonist with a K i value of 4.8. The K d value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V 1a R

In Vivo

L-372662 is an antagonist of oxytocin-induced uterine contractions in late gestation pregnant rhesus monkeys (AD50 = 36 micrograms/kg), oral bioavailability (F = 90% in dogs), and aqueous solubility (10 mg/mL). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Ki: 4.8 (oxytocin)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

L-372662 is a potent and orally active non-peptide oxytocin antagonist with a K i value of 4.8. The K d value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V 1a R.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

ANTAGONIST

이름과 식별자

이성체 SMILES

CC1=C(C=CC=[N+]1[O-])CN2CCC(CC2)OC3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5C6=CC=CC=C6COC5=O)OC

대체 CAS

162045-26-3

PubChem CID

5311202

MeSH 용어

1-(1-4-(1-(2-methyl-1-oxidopridin-3-ylmetyhl)piperidin-4-yloxyl-2-methoxybenzoyl)piperidin-4-yl)-1,4-dihydrobenz(d)(1,3)oxazin-2-one;L 372662;L-372662

분자량

586.68

관련 대상(인간)

OXTR Tclin Oxytocin receptor (0 Activities)

Discover Target: OXTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 162045-26-3, the molecular formula is C33H38N4O6, and the molecular weight is 586.68 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.