Lincomycin hydrochloride - ≥95% , CAS No.859-18-7

CAS: 859-18-7 Cat. No.: L107359 분자식: C₁₈H₃₄N₂O₆S·HCl 분자량: 443 EC 번호: 212-726-7

GRADE & PURITY ≥95%

Synonyms

CCG-220302 | Lincomycin (hydrochloride) | Lincogap | NCGC00159326-02 | Lincomycin hydrochloride, >=95.0% (TLC) | Lincomycin hydrochloride, BioReagent, suitable for cell culture | DTXCID9027780 | Lincomycin HCl (Lincocin) | POUMFISTNHIPTI-BOMBIWCESA-N | D-

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

동의어

CCG-220302 | Lincomycin (hydrochloride) | Lincogap | NCGC00159326-02 | Lincomycin hydrochloride, >=95.0% (TLC) | Lincomycin hydrochloride, BioReagent, suitable for cell culture | DTXCID9027780 | Lincomycin HCl (Lincocin) | POUMFISTNHIPTI-BOMBIWCESA-N | D-

사양 및 순도

≥95%

생화학 및 생리적 메커니즘

Antibiotic. Bacterial protein synthesis inhibitor. Cross-links peptidyl transferase loop region of 23S rRNA. Anti-bacterial agent. Active in vivo and in vitro .

보관 조건

Store at 2-8°C

배송

Wet ice

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참고

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥95%

이름과 식별자

• Pubchem Sid: 504753914
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504753914
• 정식 스마일: CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl
• IUPAC Name: (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
• InChIKey: POUMFISTNHIPTI-BOMBIWCESA-N
• INCHI: 1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
• 이성체 SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O.Cl
• 대체 CAS: 7179-49-9
• 분자량: 443
• Reaxy-Rn: 24870211
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24870211&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 분류 Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Proline and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 분류: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Proline and derivatives
• Alternative Parents: Alpha amino acid amides Thioglycosides Pyrrolidinecarboxamides Oxanes N-alkylpyrrolidines Monosaccharides Monothioacetals Trialkylamines Secondary carboxylic acid amides Secondary alcohols Sulfenyl compounds Polyols Oxacyclic compounds Azacyclic compounds Hydrochlorides Hydrocarbon derivatives Carbonyl compounds Organic oxides Organopnictogen compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Proline or derivatives - Alpha-amino acid amide - Glycosyl compound - S-glycosyl compound - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Monosaccharide - Oxane - N-alkylpyrrolidine - Monothioacetal - Pyrrolidine - Carboxamide group - Secondary alcohol - Secondary carboxylic acid amide - Tertiary amine - Tertiary aliphatic amine - Sulfenyl compound - Organoheterocyclic compound - Azacycle - Oxacycle - Polyol - Carbonyl group - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Alcohol - Organic nitrogen compound - Amine - Hydrochloride - Aliphatic heteromonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as proline and derivatives. These are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

관련 대상(비인간)

Galc Galactocerebrosidase (11 Activities)

Discover Target: Galc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 분자량: 443.000 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 442.19 Da
• Monoisotopic Mass: 442.19 Da
• Topological Polar Surface Area: 148.000 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 498.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

참고 문헌

1. Fan Yunfeng, Liu Zhimin, Wang Jie, Cui Chen, Hu Leqian.  (2022)  An “off–on” electrochemiluminescence aptasensor for determination of lincomycin based on CdS QDs/carboxylated g-C3N4.  MICROCHIMICA ACTA,  190  (1): (1-9).  [PMID:36477444] [10.1007/s00604-022-05587-w]

2. Zhi-feng Cai, Hao-yang Li, Xian-song Wang, Can Min, Jia-qi Wen, Rui-xin Fu, Zi-yue Dai, Jing Chen, Ming-zhu Guo, Hui-juan Yang, Ping-ping Bai, Xiao-mi Lu, Tao Wu, Ying Wu.  (2022)  Highly luminescent copper nanoclusters as temperature sensors and “turn off” detection of oxytetracycline.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2022.129202]

3. Yu-yu Guo, Yu-rui Hu, Shao-ke Chen, Ming-zhu Guo, Yi-ting Zhang, Xin-rui Han, Shen Zhang.  (2021)  Facile one-pot synthesis of tannic acid-stabilized fluorescent copper nanoclusters and its application as sensing probes for chlortetracycline based on inner filter effect.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2021.127962]

4. Gongxi Qiao, Gui Chen, Qin Wen, Wanqiang Liu, Jinwei Gao, Zhiqiang Yu, Qianming Wang.  (2020)  Rapid conversion from common precursors to carbon dots in large scale: Spectral controls, optical sensing, cellular imaging and LEDs application.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:32682119] [10.1016/j.jcis.2020.07.034]

5. Yumin Leng, Fang Hu, Chunhua Ma, Chenxi Du, Linfeng Ma, Jiao Xu, Qiyuan Lin, Zhipei Sang, Zhiwen Lu.  (2019)  Simple, rapid, sensitive, selective and label-free lincomycin detection by using HAuCl4 and NaOH.  RSC Advances,  9  (48): (28248-28252).  [PMID:35530481] [10.1039/C9RA04095A]

6. Pengcheng Xing, Di Wu, Jingshuai Chen, Jiming Song, Changjie Mao, Yuanhao Gao, Helin Niu.  (2019)  A Cd-MOF as a fluorescent probe for highly selective, sensitive and stable detection of antibiotics in water.  ANALYST,  144  (8): (2656-2661).  [PMID:30843538] [10.1039/C8AN02442A]

7. Qiong Ouyang, Fangying Kou, Nuanqin Zhang, Jintao Lian, Guoquan Tu, Zhanqiang Fang.  (2019)  Tea polyphenols promote Fenton-like reaction: pH self-driving chelation and reduction mechanism.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2019.02.078]

8. Bo Gao, Shaonan Dong, Jiadong Liu, Lifen Liu, Qiqi Feng, Na Tan, Tingting Liu, Longli Bo, Lei Wang.  (2016)  Identification of intermediates and transformation pathways derived from photocatalytic degradation of five antibiotics on ZnIn2S4.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2016.07.029]

9. Xiuzhong Wang, Shanshan Dong, Panpan Gai, Rui Duan, Feng Li.  (2016)  Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy.  BIOSENSORS & BIOELECTRONICS,      [PMID:27040941] [10.1016/j.bios.2016.03.055]

10. Hui Zhao, Zhen Wei, Shuxin Xu, Minjie Tang, Liandong Deng, Jianhua Zhang, Anjie Dong.  (2015)  Retracted Article: Preparation and Properties of Polymer Micelle-embedded Nanofibrous Membranes for Dual-drug Co-delivery and Multistep Release.  RSC Advances,      [PMID:] [10.1039/C5RA03345D]

11. Yin-Xia Sun, Bo-Tao Ji, Jiang-Hai Chen, Li-Ping Liu, Lu-Lu Gao, Zhe-Peng Deng, Yu Sun, Jian-Jun Wang, Biao Zhao, Jin-Guo Li.  (2024)  A smartphone-integrated bimetallic ratiometric fluorescent probe for specific visual detection of tetracycline antibiotics in food samples and latent fingerprinting.  FOOD CHEMISTRY,      [PMID:39486281] [10.1016/j.foodchem.2024.141782]

12. Yiyao Liu, Menglong Liu, Jingyi Xiao, Yi Ren, Jinyang Li, Jiayan Gao, Litao Chen, Xue Gao.  (2025)  A ratiometric fluorescence biosensor based on enzyme-cascade signal amplification technology for the detection of lincomycin.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2025.111344]

13. Qiaonan Wang, Mingyao Yu, Han Dong, Jingjing Duan, Yanxia Ding, Jinxiao Wang, Yujie Guo, Yaqian Huang, Tao Zhang, Xiaoxing Dong, Fengzhi Piao, Zhixin Guo.  (2026)  Abscisic acid confers antibiotic stress tolerance in cucumber by alleviating antibiotic phytotoxicity and decreasing the levels of antibiotic and antibiotic resistance genes.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:41506203] [10.1016/j.jhazmat.2026.141060]

14. Qinghua Wang, Dan Li, Yue Wu, Yang Zhang, Dongjing Wang, Xiuwu Lian, Zhongshun Huang, Huiying Li, Yunchong Ma, Yilin Li, Jiangyong Zeng, Lijing Cao, Honglei Ding.  (2026)  Characteristics of Mycoplasma synoviae Strains Isolated From Layer Eggs and Broiler Knee Joints or Foot Pads Mainly in Chongqing, China.  Transboundary and Emerging Diseases,  2026  (1): (2299833).  [PMID:] [10.1155/tbed/2299833]