GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥98%
Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.
In Vitro
Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.
1.Yuling Li, Weiran Zhao, Xiang Xiang, YunLei Hu, Xiaoqiang Zhang, Wenjian Sun, Xiaoxuan Liu. (2025) Untargeted Lipidomic Deep-Profiling of Human Plasma via High-Performance Aza-Prilezhaev Aziridination-LC-MS: Unraveling C=C Isomeric Signatures of Charcot-Marie-Tooth Disease. ANALYTICA CHIMICA ACTA, [PMID:40825640][10.1016/j.aca.2025.344428]
2.Lei huang, Siyuan Tang, Jiachen Guo, Yixing Tu, Sian Li, Xianchao Dai, Taihua Yang, Dong Zhao, Chao Wang. (2025) Tumor-retained lipid nanoparticle-microneedle systems for codelivery of SARS-CoV-2 mRNA and indocyanine green for synergistic immuno-photothermal therapy of superficial tumors. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:41241352][10.1016/j.ijbiomac.2025.149038]
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