LIT-001 - 10mM in DMSO , CAS No.2245072-21-1

CAS: 2245072-21-1 Cat. No.: L654789 분자식: C₃₀H₃₄F₃N₇O₄S 분자량: 645.7 PubChem CID: 145711713

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist ( EC 50 =55 nM; K i =226 nM). LIT-001 improves social interaction in a mouse model of autism

In Vitro

In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Oprm1 –/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background) Dosage: 10, 20 mg/kg Administration: i.p. Result: Alleviated core symptoms in the context of ASD.

IC50& Target:EC50: 55 nM (OT-R), Ki: 226 nM (OT-R)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist ( EC 50 =55 nM; K i =226 nM). LIT-001 improves social interaction in a mouse model of autism.

보관 조건

Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

AGONIST

이름과 식별자

• PubChem CID: 145711713
• MeSH 용어: (S)-2-(Dimethylcarbamothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo(b)pyrazolo(3,4-e)(1,4)diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide 2,2,2-trifluoroacetate;LIT-001
• 분자량: 645.7

자주 묻는 질문

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2245072-21-1, the molecular formula is C30H34F3N7O4S, and the molecular weight is 645.7 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.