루파리엘라이드 - ≥98% , CAS No.111149-87-2

CAS: 111149-87-2 Cat. No.: L274847 분자식: C₂₅H₃₈O₃ 분자량: 386.57 PubChem CID: 5387248

GRADE & PURITY ≥98%

Synonyms

BDBM50478547 | SMP2_000178 | AKOS025294086 | CHEBI:181926 | J-002531 | Luffariellolide | 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one | NSC622149 | NSC-622149 | 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trim

Storage

빛으로부터 보호, -20°C에서 건조 보관

Shipped In

아이스 박스 + 아이스 패드

개요

루파리엘라이드는 인간 활액 포스포리파아제 A2(HSF-PLA2)의 억제제입니다(IC50=5 μM). 루파리엘라이드는 포볼 에스테르(PMA)로 인한 귀 부종을 효과적으로 억제합니다(ED50=50 μg/귀).

Specifications

동의어

BDBM50478547 | SMP2_000178 | AKOS025294086 | CHEBI:181926 | J-002531 | Luffariellolide | 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one | NSC622149 | NSC-622149 | 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trim

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

강력한 부분 가역성 포스포리파아제 A2(PLA 2 ) 억제제(IC 50 = 5 µM). 또한 새로운 RARα 작용제(EC 50 = 1 μM)입니다. 해양 스폰지 루파리엘라의 유도체 항염증 활성을 나타내며 생체 내에서 활성 .

보관 조건

빛으로부터 보호, -20°C에서 건조 보관

배송

아이스 박스 + 아이스 패드

작업 유형

INHIBITOR

참고

가능하면 당일에 용액을 준비하여 사용하는 것이 좋습니다. 그러나 미리 원액을 만들어야 하는 경우에는 -20°C에서 단단히 밀봉된 바이알에 소량씩 보관하는 것이 좋습니다. 일반적으로 최대 한 달 동안 사용할 수 있습니다. 사용하기 전에 바이알을 개봉하기 전에 제품을 실온에서 1시간 이상 평형화할 것을 권장합니다. 용해도, 사용법 및 취급에 대한 추가 정보가 필요하신가요? 자주 묻는 질문(FAQ) 페이지에서 자세한 내용을 확인하세요.

순수함

≥98%

이름과 식별자

• 정식 스마일: CC1=C(C(CCC1)(C)C)CCC(=CCCC(=CCCC2=CC(=O)OC2O)C)C
• IUPAC Name: 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one
• InChIKey: JPWPYTMXSXYUPG-QZPYEDBESA-N
• INCHI: 1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
• 이성체 SMILES: CC1=C(C(CCC1)(C)C)CC/C(=C/CC/C(=C/CCC2=CC(=O)OC2O)/C)/C
• PubChem CID: 5387248
• 분자량: 386.57

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • 분류 Prenol lipids
      • Subclass Terpene lactones

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• 분류: Prenol lipids
• Subclass: Terpene lactones
• Intermediate Tree Nodes: Not available
• Direct Parent: Diterpene lactones
• Alternative Parents: Diterpenoids Butenolides Enoate esters Lactones Hemiacetals Oxacyclic compounds Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Diterpene lactone - Diterpenoid - 2-furanone - Dihydrofuran - Enoate ester - Alpha,beta-unsaturated carboxylic ester - Carboxylic acid ester - Hemiacetal - Lactone - Oxacycle - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Carbonyl group - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Aliphatic heteromonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

PLA2G2A Tchem Phospholipase A2 group IIA (1079 Activities)

Discover Target: PLA2G2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

T47D (39041 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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관련 대상(비인간)

Phospholipase A2 (8 Activities)

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Staphylococcus aureus (210822 Activities)

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Escherichia coli (133304 Activities)

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Bacillus subtilis (32866 Activities)

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Candida albicans (78123 Activities)

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L5178Y (1809 Activities)

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PC-12 (7051 Activities)

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Cladosporium herbarum (157 Activities)

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작용 메커니즘

화학 및 물리적 특성

• 용해성: Soluble in DMSO and in ethanol
• 감도: light sensitive
• 분자량: 386.600 g/mol
• XLogP3: 6.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 386.282 Da
• Monoisotopic Mass: 386.282 Da
• Topological Polar Surface Area: 46.500 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 689.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 111149-87-2, the molecular formula is C25H38O3, and the molecular weight is 386.57 g/mol. InChIKey JPWPYTMXSXYUPG-QZPYEDBESA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.