Manidipine - Moligand™, 10mM in DMSO , CAS No.89226-50-6

CAS: 89226-50-6 Cat. No.: M408490 분자식: C₃₅H₃₈N₄O₆ 분자량: 610.699 EC 번호: 855-394-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1,​4-​dihydro-​2,​6-​dimethyl-​4-​(3-​nitrophenyl)​-3,​5-​pyridinedicarboxylic acid 3-​[2-​[4-​(diphenylmethyl)​-​1-​piperazinyl]​ethyl] 5-​methyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Manidipine Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
In vitro

Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer. Manidipine inhibits the ET-1-induced [Ca2+]i increase by reducing both the transient and sustained Ca2+ increments in A7r5 cells and glomerular mesangial cells (MCs). Manidipine (10(-5) mol/L) potentiates ET-1-induced c-fos and c-jun expression in A7r5 cells. Manidipine is a potent inhibitor for ET-1-induced [Ca2+]i signaling and that Manidipine has multiple effects on ET-1-induced signaling, including potentiating the immediate-early gene response.

In vivo

Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. Manidipine combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion. Manidipine hydrochloride prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy. Manidipine HCl increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats.
Cell Data

cell lines：HsSultan and NB4 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

동의어

1,​4-​dihydro-​2,​6-​dimethyl-​4-​(3-​nitrophenyl)​-3,​5-​pyridinedicarboxylic acid 3-​[2-​[4-​(diphenylmethyl)​-​1-​piperazinyl]​ethyl] 5-​methyl ester

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

이름과 식별자

• 이성체 SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC
• 대체 CAS: 89226-50-6,89226-75-5 (di-hydrochloride)
• MeSH 용어: (+)-manidipine;(+)-manidipine dihydrochloride;(-)-manidipine;(-)-manidipine dihydrochloride;(R)-(-)-manidipine;(R)-(-)-manidipine dihydrochloride;(R)-manidipine;(R)-manidipine dihydrochloride;(S)-(+)-manidipine;(S)-(+)-manidipine dihydrochloride;(S)-manid
• 분자량: 610.699
• Reaxy-Rn: 5788174
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5788174&ln=