Mardepodect hydrochloride - ≥95% , CAS No.2070014-78-5

CAS: 2070014-78-5 Cat. No.: M649719 분자식: C₂₅H₂₁ClN₄O 분자량: 428.91 PubChem CID: 122412737

GRADE & PURITY ≥95%

Synonyms

2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline;hydrochloride | PF-2545920 (hydrochloride) | MS-27603 | Quinoline, 2-((4-(1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-, hydrochloride (1:1) | LTZ83KS2UW | Mardepodect hydroch

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

개요

Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs . Mardepodect hydrochloride can cross the blood-brain barrier

In Vivo

In the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED 50 of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 0.37 nM (PDE10A)

Specifications

동의어

2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline;hydrochloride | PF-2545920 (hydrochloride) | MS-27603 | Quinoline, 2-((4-(1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-, hydrochloride (1:1) | LTZ83KS2UW | Mardepodect hydroch

사양 및 순도

≥95%

생화학 및 생리적 메커니즘

Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs . Mardepodect hydrochloride can cross the blood-brain barrier.

보관 조건

Store at 2-8°C,Desiccated

배송

Wet ice

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작업 유형

INHIBITOR

순수함

≥95%

이름과 식별자

정식 스마일

CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C5=CC=NC=C5.Cl

IUPAC Name

2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline;hydrochloride

InChIKey

BDHTXAXWOXYUDG-UHFFFAOYSA-N

INCHI

1S/C25H20N4O.ClH/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21;/h2-16H,17H2,1H3;1H

이성체 SMILES

CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C5=CC=NC=C5.Cl

대체 CAS

2070014-78-5

PubChem CID

122412737

분자량

428.91

화학 및 물리적 특성

• 용해성: DMSO : 25 mg/mL (58.29 mM; Need ultrasonic)
• 분자량: 428.900 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 428.14 Da
• Monoisotopic Mass: 428.14 Da
• Topological Polar Surface Area: 52.800 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 531.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2070014-78-5, the molecular formula is C25H21ClN4O, and the molecular weight is 428.91 g/mol. InChIKey BDHTXAXWOXYUDG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.