MB710 - 10mM in DMSO , CAS No.2230044-57-0

CAS: 2230044-57-0 Cat. No.: M655510 분자식: C₁₆H₁₆IN₃O₃S 분자량: 457.29 PubChem CID: 133082032

등급 & 순도 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C . MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C , with a K d of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines

In Vitro

MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all cell lines tested at concentrations up to 60 μM, while showing initial selective viability reduction at higher concentrations. MB710 (72 hours) treats cancer cell lines NUGC3, NUGC4, WI38 and SW1088, with IC 50 s of 90, 120, >120, >120 μM, respectively. MB710 (0-120 μM; 72 hours; HUH-7 cells) shows stronger cytotoxic effects in presence of p53-Y220C. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT) Concentration: 0-200 μM Incubation Time: 72 hours Result: Showed relatively low toxicity against all cell lines tested at concentrations up to 60 μM. NUGC3 was the most sensitive cell line.

IC50& Target:Kd: 4 μM (p53-Y220C)

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C . MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C , with a K d of 4.1u202fμM. MB710 shows anticancer activity in p53-Y220C cell lines.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

CCN(CC)C1=NC2=C(C(=C(C(=C2S1)N3C=CC=C3)I)O)C(=O)O

PubChem CID

133082032

분자량

457.29

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2230044-57-0, the molecular formula is C16H16IN3O3S, and the molecular weight is 457.29 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.