Milrinone - Moligand™, 10mM in DMSO , Inhibitor of phosphodiesterase 2A;Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B;Inhibitor of phosphodiesterase 5A, CAS No.78415-72-2, Inhibitor of phosphodiesterase 2A;Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B;Inhibitor of phosphodiesterase 5A
Milrinone - Moligand™, 10mM in DMSO , Inhibitor of phosphodiesterase 2A;Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B;Inhibitor of phosphodiesterase 5A, CAS No.78415-72-2, Inhibitor of phosphodiesterase 2A;Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B;Inhibitor of phosphodiesterase 5A
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
Information
Milrinone (Win 47203) is aphosphodiesterase 3 (PDE3)inhibitor, used to increase the heart's contractility. In vitro
Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Milrinone inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM.Milrinone concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. Milrinone concentration-dependently increases cAMP in rabbit coronary smooth muscle cells. Milrinone increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase. Milrinone is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. Milrinone significant increases in cAMP content accompany significant vasorelaxation.
In vivo
Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.Milrinone (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol. Milrinone causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs. Milrinone leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. Cell Data
1.Ru Li, Xuan Zou, Pan Luan, Xiaokun Liu, Ning Wang, Qian Wang, Huashi Guan, Zhe Xu. (2022) Direct Determination of Enzymes in Dried Blood Spots by High-Performance Liquid Chromatography – Mass Spectrometry (HPLC-MS) for the Screening of Antithrombotic Agents. ANALYTICAL LETTERS, [PMID:][10.1080/00032719.2022.2053700]
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