MK-6884 - ≥99% , CAS No.2102194-04-5

CAS: 2102194-04-5 Cat. No.: M650201 분자식: C₂₅H₂₅N₅O 분자량: 411.50

등급 & 순도 ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a K i value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent

In Vitro

MK-6884 (compound 13; 0-22 µM) is a PAM of ACh function in a cell-based Ca 2+ mobilization assay, with an EC 50 of 27 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[ 11 C]MK-6884 (compound 13) shows non-displaceable binding potential (BP ND ) of 0.83 in rhesus monkeys . [ 11 C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain . [ 11 C]MK-688 can penetrate the blood-brain barrier in monkeys . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:mAChR4

사양

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a K i value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emissio

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

MODULATOR

순수함

≥99%

이름과 식별자

분자량

411.50

화학 및 물리적 특성

• 용해성: THF : 3.33 mg/mL (8.09 mM; Need ultrasonic)